1. PROTAC
    Autophagy
    Apoptosis
    Immunology/Inflammation
  2. PROTAC
    FKBP
  3. PROTAC FKBP Degrader-3

PROTAC FKBP Degrader-3 

Cat. No.: HY-135345
Handling Instructions

PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader.

For research use only. We do not sell to patients.

PROTAC FKBP Degrader-3 Chemical Structure

PROTAC FKBP Degrader-3 Chemical Structure

CAS No. : 2079056-43-0

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Description

PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].

IC50 & Target[1]

VHL

 

FKBP

 

In Vitro

PROTAC treatment time courses demonstrated a notable increase in polyubiquitination of EGFP-FKBP in response to treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) for VHL within the first hour. Upon recruiting endogenous VHL via PROTAC FKBP Degrader-3 (compound 10), only one EGFP background lysine (Lys158) is found to be ubiquitylated[1].

Molecular Weight

1295.54

Formula

C₆₈H₉₀N₆O₁₇S

CAS No.

2079056-43-0

SMILES

CC[[email protected]](C(N1[[email protected]](C(O[[email protected]](CCC2=CC=C(OC)C(OC)=C2)C3=CC=CC(OCC(NCCOCCOCCOCC(N[[email protected]@H](C(C)(C)C)C(N4C[[email protected]](O)C[[email protected]]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O)=C3)=O)CCCC1)=O)C7=CC(OC)=C(OC)C(OC)=C7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PROTAC FKBP Degrader-3PROTAC FKBP Degrader3PROTAC FKBP Degrader 3PROTACFKBPProteolysis-targeting chimeraFK506-binding proteinubiquitinationVHL-liganddegradationLys158endogenousE3-ligaseInhibitorinhibitorinhibit

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PROTAC FKBP Degrader-3
Cat. No.:
HY-135345
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