1. Apoptosis
    Immunology/Inflammation
    Autophagy
  2. FKBP
  3. SAFit1

SAFit1 

Cat. No.: HY-102079
Handling Instructions

SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM.

For research use only. We do not sell to patients.

SAFit1 Chemical Structure

SAFit1 Chemical Structure

CAS No. : 1643125-32-9

Size Price Stock
5 mg USD 450 Get quote
10 mg USD 650 Get quote
25 mg USD 1400 Get quote
50 mg USD 2200 Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM[1][2].

IC50 & Target

Ki: 4±0.3 nM (FKBP51), >50000 nM (FKBP52)[1]

In Vitro

SAFit1 (1-1000 nM) potently stimulates neurite outgrowth in two neuronal cell lines (N2a and SH-SY5Y) as well as in primary hippocampal neurons. SAFit1 is active over a wide concentration range[1].

Molecular Weight

747.87

Formula

C₄₂H₅₃NO₁₁

CAS No.

1643125-32-9

SMILES

O=C(N1[[email protected]@H](CCCC1)C(O[[email protected]@H](C2=CC(OCC(O)=O)=CC=C2)CCC3=CC(OC)=C(OC)C=C3)=O)[[email protected]@H](C4CCCCC4)C5=CC(OC)=C(OC)C(OC)=C5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 125 mg/mL (167.14 mM; Need ultrasonic)

DMSO : 62.5 mg/mL (83.57 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3371 mL 6.6857 mL 13.3713 mL
5 mM 0.2674 mL 1.3371 mL 2.6743 mL
10 mM 0.1337 mL 0.6686 mL 1.3371 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SAFit1
Cat. No.:
HY-102079
Quantity: