WIZ degrader 3
WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia.
For research use only. We do not sell to patients.
- CAS No.: 2839637-72-6
- Formula: C18H23N5O3
- Molecular Weight:357.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Widely Interspaced Zinc Finger Motifs (WIZ)[1]
WIZ degrader 3 upregulates of fetal hemoglobin genes (HBG1/2) expression and induces fetal hemoglobin (HbF) expression in human primary erythroid cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2839637-72-6
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Molecular Weight 357.41
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Formula C18H23N5O3
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SMILES
O=C(NC(CC1)=O)N1C2=NOC3=CC=C(C=C23)CN4C[C@@H](N(CC4)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WIZ degrader 3 Related Classifications
HY-163819 Related Classifications
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