2839637-72-6
2839637-72-6
Chemical Structure
WIZ degrader 3
- CAS No.: 2839637-72-6
- Formula:C18H23N5O3
- Molecular Weight:357.41
InChIKey: ITMHVHSSTZYQAN-LBPRGKRZSA-N
SMILES: O=C(NC(CC1)=O)N1C2=NOC3=CC=C(C=C23)CN4C[C@@H](N(CC4)C)C
Biological Activity: WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia[1].
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WIZ degrader 3 | WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia. | |||||||||||||||||||||
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References
Keywords
