1. PROTAC
    Apoptosis
    Metabolic Enzyme/Protease
  2. PROTAC
    MDM-2/p53
    E1/E2/E3 Enzyme
  3. PROTAC MDM2 Degrader-3

PROTAC MDM2 Degrader-3 

Cat. No.: HY-128842 Purity: 98.69%
Handling Instructions

PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

For research use only. We do not sell to patients.

PROTAC MDM2 Degrader-3 Chemical Structure

PROTAC MDM2 Degrader-3 Chemical Structure

CAS No. : 2249750-23-8

Size Price Stock Quantity
1 mg USD 320 In-stock
Estimated Time of Arrival: December 31
5 mg USD 950 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase[1].

IC50 & Target

MDM2

 

Molecular Weight

1437.25

Formula

C₇₂H₇₈Cl₄N₈O₁₅

CAS No.

2249750-23-8

SMILES

O=C(N1CC(N(CC(OCCOCCOCCOCCOC(CN2C(CN(C(N3[[email protected]](C4=CC=C(Cl)C=C4)[[email protected]](C5=CC=C(Cl)C=C5)N=C3C6=C(C=C(OC)C=C6)OC(C)C)=O)CC2)=O)=O)=O)CC1)=O)N7[[email protected]](C8=CC=C(Cl)C=C8)[[email protected]](C9=CC=C(Cl)C=C9)N=C7C%10=C(C=C(OC)C=C%10)OC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (6.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6958 mL 3.4789 mL 6.9577 mL
5 mM 0.1392 mL 0.6958 mL 1.3915 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

PROTAC MDM2 Degrader-3PROTACMDM-2/p53E1/E2/E3 EnzymeProteolysis-targeting chimeraE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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PROTAC MDM2 Degrader-3
Cat. No.:
HY-128842
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