2. PROTAC Apoptosis
  3. PROTACs MDM-2/p53
  4. PROTAC MDM2 Degrader-3

PROTAC MDM2 Degrader-3 is a MDM2 self-degrading (dimeric) PROTAC. PROTAC MDM2 Degrader-3 can be used in cancer research.
(Pink: MDM2 ligand (HY-128837); Blue: MDM2 ligand (HY-128837); Black: linker (HY-W018745)).

For research use only. We do not sell to patients.

PROTAC MDM2 Degrader-3

PROTAC MDM2 Degrader-3 Chemical Structure

CAS No. : 2249750-23-8

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Customer Review

Based on 1 publication(s) in Google Scholar

PROTAC MDM2 Degrader-3 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PROTAC MDM2 Degrader-3

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC MDM2 Degrader-3 is a MDM2 self-degrading (dimeric) PROTAC. PROTAC MDM2 Degrader-3 can be used in cancer research[1]. (Pink: MDM2 ligand (HY-128837); Blue: MDM2 ligand (HY-128837); Black: linker (HY-W018745)).

IC50 & Target

MDM2

 

In Vitro

PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC MDM2 Degrader-3 Related Antibodies
Molecular Weight

1437.25

Formula

C72H78Cl4N8O15
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CC(N(CC(OCCOCCOCCOCCOC(CN2C(CN(C(N3[C@H](C4=CC=C(Cl)C=C4)[C@H](C5=CC=C(Cl)C=C5)N=C3C6=C(C=C(OC)C=C6)OC(C)C)=O)CC2)=O)=O)=O)CC1)=O)N7[C@H](C8=CC=C(Cl)C=C8)[C@H](C9=CC=C(Cl)C=C9)N=C7C%10=C(C=C(OC)C=C%10)OC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (6.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6958 mL 3.4789 mL 6.9577 mL
5 mM 0.1392 mL 0.6958 mL 1.3915 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6958 mL 3.4789 mL 6.9577 mL 17.3943 mL
5 mM 0.1392 mL 0.6958 mL 1.3915 mL 3.4789 mL
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PROTAC MDM2 Degrader-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC MDM2 Degrader-32249750-23-8PROTACsMDM-2/p53Inhibitorinhibitorinhibit

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