PROTAC SMARCA2/4 degrader-43
PROTAC SMARCA2/4 degrader-43 is a PROTAC degrader targeting SMARCA2/4, which induces ubiquitination and proteasomal degradation of the protein. PROTAC SMARCA2/4 degrader-43 is applicable to cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159542); Blue: Cereblon ligand (HY-W023573); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2568276-73-1
- Formula: C37H39N9O5
- Molecular Weight:689.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SMARCA2 |
SMARCA4 |
PROTAC SMARCA2/4 degrader-43 (I-323) (24 h) potently degrades SMARCA2 protein in A549 cells with a DC50 < 100 nM and > 90% maximum degradation after 24-hour incubation[1].
PROTAC SMARCA2/4 degrader-43 (24 h) potently degrades SMARCA4 protein in MV4-11 cells with a DC50 < 100 nM and > 90% maximum degradation after 24-hour incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2568276-73-1
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Molecular Weight 689.76
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Formula C37H39N9O5
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SMILES
O=C1NC(C(CC1)N2C(C3=CC=C(NC4CCC(CC4)N5CCC(CC5)N6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)C=C3C2=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2/4 degrader-43 Related Classifications
HY-163866 Related Classifications
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