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Cat. No.: HY-153536

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PROTAC BTK Degrader-3

PROTAC BTK Degrader-3 is a potent BTK degrader with a DC₅₀ value of 10.9 nM of BTK degradation in Mino cells. PROTAC BTK Degrader-3 has the potential for B-cell malignancies, including chronic lymphoid malignancies research.
(Pink: Btk ligand (HY-150885); Blue: Cereblon ligand (HY-14658); Black: linker (HY-W125996)).

For research use only. We do not sell to patients.

CAS No.: 2563861-90-3
Formula: C₄₁H₄₀N₁₀O₅
Molecular Weight:752.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC BTK Degrader-3 Chemical Structure

CAS No.: 2563861-90-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC BTK Degrader-3 is a potent BTK degrader with a DC₅₀ value of 10.9 nM of BTK degradation in Mino cells. PROTAC BTK Degrader-3 has the potential for B-cell malignancies, including chronic lymphoid malignancies research^[1]. (Pink: Btk ligand (HY-150885); Blue: Cereblon ligand (HY-14658); Black: linker (HY-W125996)).

All PROTACs Isoforms :

Chemical Information

CAS No. 2563861-90-3
Molecular Weight 752.82
Formula C₄₁H₄₀N₁₀O₅
SMILES

O=C1C2=CC=C(N3CC(C3)N4CC(C4)N5CCC(CC5)N6N=C(C7=C6N=CN=C7N)C8=CC=C(OC9=CC=CC=C9)C=C8)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhangchen, et al. Salt of compound for degrading btk, crystal form thereof, and use thereof in medicine. Patent WO2022052950A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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