2563861-90-3
Chemical Structure
PROTAC BTK Degrader-3
- CAS No.: 2563861-90-3
- Formula:C41H40N10O5
- Molecular Weight:752.82
IUPAC Name: 5-(3-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-[1,3'-biazetidin]-1'-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChIKey: BORJZCDAUJWRDI-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(N3CC(C3)N4CC(C4)N5CCC(CC5)N6N=C(C7=C6N=CN=C7N)C8=CC=C(OC9=CC=CC=C9)C=C8)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O
Biological Activity: PROTAC BTK Degrader-3 is an orally active PROTAC degrader targeting BTK, with a DC50 value of 10.9 nM. PROTAC BTK Degrader-3 has an IC50 of 6.3 nM against wild-type BTK and an IC50 of 8 nM against BTKC481S. PROTAC BTK Degrader-3 can be used in cancer-related research[1].
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PROTAC BTK Degrader-3 | PROTAC BTK Degrader-3 is an orally active PROTAC degrader targeting BTK, with a DC50 value of 10.9 nM. PROTAC BTK Degrader-3 has an IC50 of 6.3 nM against wild-type BTK and an IC50 of 8 nM against BTKC481S. PROTAC BTK Degrader-3 can be used in cancer-related research. | |||||||||||||||||||||
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