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Cat. No.: HY-135558

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PROTAC BRD4 Degrader-3

PROTAC BRD4 Degrader-3 is a VHL-recruiting PROTAC degrader that targets BRD4. PROTAC BRD4 Degrader-3 consists of a VHL E3 ubiquitin ligase ligand and a BRD4 inhibitor linked by a connector.
(Pink: BRD4 ligand (HY-129939); Blue: VHL ligand (HY-184670); Black: linker (HY-W014831)).

For research use only. We do not sell to patients.

CAS No.: 2313234-00-1
Formula: C₅₅H₆₅F₂N₉O₉S₂
Molecular Weight:1098.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PROTAC BRD4 Degrader-3 Chemical Structure

CAS No.: 2313234-00-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC BRD4 Degrader-3 is a VHL-recruiting PROTAC degrader that targets BRD4. PROTAC BRD4 Degrader-3 consists of a VHL E3 ubiquitin ligase ligand and a BRD4 inhibitor linked by a connector^[1]. (Pink: BRD4 ligand (HY-129939); Blue: VHL ligand (HY-184670); Black: linker (HY-W014831)).

IC₅₀ & Target

^[1]

BRD4

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

PROTAC BRD4 Degrader-3 (example 1004.1) exhibits an IC₅₀ of 1.85 μM and a Kd of 0.0801 μM against VHL in FP assays and HEK-293 BRET assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2313234-00-1
Molecular Weight 1098.29
Formula C₅₅H₆₅F₂N₉O₉S₂
SMILES

O=C1C2=C(C(CN(C(N=CC(F)=C3)=C3F)C4=C5)=CN2)C(C4=CC(C[S](C)(=O)=O)=C5C(NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]6O)[C@@H](C6)C(NOC7=CC=C(C(SC=N8)=C8C)C=C7)=O)=O)=O)=O)=CN1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Peter Dragovich, et al. (4-hydroxypyrrolidin-2-yl)-hydroxamate compounds and methods of use thereof. WO2019084030A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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