LCK degrader-3
LCK degrader-3 (Compound 20) is a CRBN-based LCK molecular glue degrader. LCK degrader-3 can be used in the research of acute lymphoblastic leukemia.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3095032-59-7
- Formel: C24H22N4O4
- Molecular Weight:430.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Lck |
Cereblon |
In Vitro
CRBN, or Cereblon protein, is the substrate recognition subunit of the Cullin 4-RING E3 ubiquitin ligase complex. Immunomodulatory drugs (thalidomide and its derivatives) directly bind to CRBN, altering its substrate specificity and enabling it to recognize and degrade transcription factors such as IKZF1/3, thereby exerting anti-tumor effects.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3095032-59-7
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Molecular Weight 430.46
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Formel C24H22N4O4
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SMILES
O=C(C(N1)=C(CC)C2=C1C=CC=C2)NC3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4)=O)C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LCK degrader-3 Related Classifications
HY-180928 Related Classifications
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