Thalidomide-NH-CBP/p300 ligand 2

Cat. No.: HY-139707 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

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Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader (extracted from patent WO2020173440).

For research use only. We do not sell to patients.

Thalidomide-NH-CBP/p300 ligand 2 Chemical Structure

CAS No. : 2484739-21-9

Size	Price	Stock	Quantity
1 mg	USD 477	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 5300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 8500	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader (extracted from patent WO2020173440)^[1].

Molecular Weight

922.03

Formula

C₄₈H₅₇F₂N₁₁O₆

CAS No.

2484739-21-9

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(N1CC2=C(CC1)N(C3CCN(CC3)C(CCCCCCCNC4=CC=C5C(N(C6C(NC(CC6)=O)=O)C(C5=C4)=O)=O)=O)N=C2N7C8=C(CCC7)C=C(C9=CN(C)N=C9)C(C(F)F)=C8)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 113.33 mg/mL (122.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0846 mL	5.4228 mL	10.8456 mL
5 mM	0.2169 mL	1.0846 mL	2.1691 mL
10 mM	0.1085 mL	0.5423 mL	1.0846 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (248 KB) HNMR (237 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

References

[1]. LIU JING, et al. CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN (CBP) AND/OR ADENOVIRAL E1A BINDING PROTEIN OF 300 KDA (P300) DEGRADATION COMPOUNDS AND METHODS OF USE. Patent WO2020173440.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0846 mL	5.4228 mL	10.8456 mL	27.1141 mL
	5 mM	0.2169 mL	1.0846 mL	2.1691 mL	5.4228 mL
	10 mM	0.1085 mL	0.5423 mL	1.0846 mL	2.7114 mL
	15 mM	0.0723 mL	0.3615 mL	0.7230 mL	1.8076 mL
	20 mM	0.0542 mL	0.2711 mL	0.5423 mL	1.3557 mL
	25 mM	0.0434 mL	0.2169 mL	0.4338 mL	1.0846 mL
	30 mM	0.0362 mL	0.1808 mL	0.3615 mL	0.9038 mL
	40 mM	0.0271 mL	0.1356 mL	0.2711 mL	0.6779 mL
	50 mM	0.0217 mL	0.1085 mL	0.2169 mL	0.5423 mL
	60 mM	0.0181 mL	0.0904 mL	0.1808 mL	0.4519 mL
	80 mM	0.0136 mL	0.0678 mL	0.1356 mL	0.3389 mL
	100 mM	0.0108 mL	0.0542 mL	0.1085 mL	0.2711 mL