PROTAC CBP/P300 Degrader-3
Based on 1 Customer Validation
PROTAC CBP/P300 Degrader-3 (Thalidomide-NH-CBP/p300 ligand 2) is a PROTAC degrader of CBP and p300. PROTAC CBP/P300 Degrader-3 promotes ubiquitination and degradation of CBP/P300. It can be used in the research of prostate cancer.
(Pink: CBP/p300 ligand (HY-138539); Blue: Cereblon ligand (HY-W087383); Black: linker).
For research use only. We do not sell to patients.
- Purity : 98.55%
- CAS No.: 2484739-21-9
- Formula: C48H57F2N11O6
- Molecular Weight:922.03
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
Cereblon |
CBP/p300 |
In Vitro
PROTAC CBP/P300 Degrader-3 (Compound P-007) at 10 nM degrades p300 in cells with a degradation rate of ≥80%[1].
PROTAC CBP/P300 Degrader-3 (3 days) inhibits the viability of LNCaP cells with an IC50 of 1.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2484739-21-9
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Appearance Solid
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Molecular Weight 922.03
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Formula C48H57F2N11O6
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Color Light yellow to green yellow
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SMILES
O=C(N1CC2=C(CC1)N(C3CCN(CC3)C(CCCCCCCNC4=CC=C5C(N(C6C(NC(CC6)=O)=O)C(C5=C4)=O)=O)=O)N=C2N7C8=C(CCC7)C=C(C9=CN(C)N=C9)C(C(F)F)=C8)NC
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Synonyms
Thalidomide-NH-CBP/p300 ligand 2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 113.33 mg/mL (122.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0846 mL | 5.4228 mL | 10.8456 mL | 27.1141 mL |
| 5 mM | 0.2169 mL | 1.0846 mL | 2.1691 mL | 5.4228 mL | |
| 10 mM | 0.1085 mL | 0.5423 mL | 1.0846 mL | 2.7114 mL | |
| 15 mM | 0.0723 mL | 0.3615 mL | 0.7230 mL | 1.8076 mL | |
| 20 mM | 0.0542 mL | 0.2711 mL | 0.5423 mL | 1.3557 mL | |
| 25 mM | 0.0434 mL | 0.2169 mL | 0.4338 mL | 1.0846 mL | |
| 30 mM | 0.0362 mL | 0.1808 mL | 0.3615 mL | 0.9038 mL | |
| 40 mM | 0.0271 mL | 0.1356 mL | 0.2711 mL | 0.6779 mL | |
| 50 mM | 0.0217 mL | 0.1085 mL | 0.2169 mL | 0.5423 mL | |
| 60 mM | 0.0181 mL | 0.0904 mL | 0.1808 mL | 0.4519 mL | |
| 80 mM | 0.0136 mL | 0.0678 mL | 0.1356 mL | 0.3389 mL | |
| 100 mM | 0.0108 mL | 0.0542 mL | 0.1085 mL | 0.2711 mL |
PROTAC CBP/P300 Degrader-3 Related Classifications
HY-139707 Related Classifications
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