PROTAC HDAC8 Degrader-3
PROTAC HDAC8 Degrader-3 (Compound BP1) is an efficient and selective HDAC8 PROTAC degrader with a DC50 of 20 nM. PROTAC HDAC8 Degrader-3 exhibits IC50 for HDAC8 and CRBN of 0.46 and 7.5 μM, respectively. PROTAC HDAC8 Degrader-3 exhibits potent anti-proliferative activity against MM.1S and HL-60 cells. PROTAC HDAC8 Degrader-3 can be used for research on multiple myeloma and acute myeloid leukemia.
(Pink: HDAC8 ligand (HY-15224); Blue: Cereblon ligand (HY-41547); Black: linker).
For research use only. We do not sell to patients.
- Formula: C38H38N8O9
- Molecular Weight:750.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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HDAC8 20 nM (DC50) |
Cereblon |
Chemical Information
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Molecular Weight 750.76
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Formula C38H38N8O9
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SMILES
O=C(C1=CC=C2C(N(C=C2)CC3=CC=C(C=C3)OCC4=CN(N=N4)CCOCCOCCNC5=C6C(C(N(C6=O)C7CCC(NC7=O)=O)=O)=CC=C5)=C1)NO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC HDAC8 Degrader-3 Related Classifications
HY-181023 Related Classifications
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