PROTAC STAT6 degrader-3

Name: PROTAC STAT6 degrader-3
Brand: MedChemExpress
SKU: HY-176919
Rating: 4.5 (0 reviews)

Cat. No.: HY-176919 Purity: 98.66%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PROTAC STAT6 degrader-3 is a potent STAT6 PROTAC degrader with a DC₅₀ of less than 1 nM. PROTAC STAT6 degrader-3 can be used for research on allergic/inflammatory diseases and cancer.

For research use only. We do not sell to patients.

PROTAC STAT6 degrader-3 Chemical Structure

CAS No. : 3077385-98-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC STAT6 degrader-3 is a potent STAT6 PROTAC degrader with a DC₅₀ of less than 1 nM. PROTAC STAT6 degrader-3 can be used for research on allergic/inflammatory diseases and cancer^[1].

In Vitro

PROTAC STAT6 degrader-3 is a potent STAT6 PROTAC degrader with a DC₅₀ of less than 1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

855.88

Formula

C₄₄H₄₅F₄N₉O₅

CAS No.

3077385-98-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C)C)C(N1)=CC2=C1C(F)=C(C3=CCCN(C(CCN4N=CC=C4)=O)C3)C=C2C5=C(F)C(F)=C(N6CCN(C7=C(F)C=C(NC8CCC(NC8=O)=O)C(OC)=C7)CC6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (58.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1684 mL	5.8419 mL	11.6839 mL
5 mM	0.2337 mL	1.1684 mL	2.3368 mL
10 mM	0.1168 mL	0.5842 mL	1.1684 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.66%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (253 KB) HNMR (367 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Bin Yang, et al. STAT6 DEGRADERS AND USES THEREOF CROSS REFERENCE TO RELATED APPLICATIONS. WO2025049820A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1684 mL	5.8419 mL	11.6839 mL	29.2097 mL
	5 mM	0.2337 mL	1.1684 mL	2.3368 mL	5.8419 mL
	10 mM	0.1168 mL	0.5842 mL	1.1684 mL	2.9210 mL
	15 mM	0.0779 mL	0.3895 mL	0.7789 mL	1.9473 mL
	20 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4605 mL
	25 mM	0.0467 mL	0.2337 mL	0.4674 mL	1.1684 mL
	30 mM	0.0389 mL	0.1947 mL	0.3895 mL	0.9737 mL
	40 mM	0.0292 mL	0.1460 mL	0.2921 mL	0.7302 mL
	50 mM	0.0234 mL	0.1168 mL	0.2337 mL	0.5842 mL