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Cat. No.: HY-178828

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E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO

E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC LRRK2 Degrader-3 (HY-178797). PROTAC LRRK2 Degrader-3 is a potent LRRK2 PROTAC degrader with anti-neuroinflammatory activity.

For research use only. We do not sell to patients.

CAS No.: 3040075-64-4
Formula: C₂₅H₃₂N₄O₅
Molecular Weight:468.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO Chemical Structure

CAS No.: 3040075-64-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 3040075-64-4
Molecular Weight 468.55
Formula C₂₅H₃₂N₄O₅
SMILES

O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C(N4CCC(CC4)O[C@@H]5CC[C@H](CC5)C=O)C=C3N1C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Renner, A. C., et al. RRK2 Degraders for Parkinson’s Disease and Inflammation: Tau and α-Synuclein Degraders for Neurodegeneration. ACS Med. Chem. Lett.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO

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E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO Related Classifications

HY-178828 Related Classifications

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