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Results for "

RAW+264.7+macrophages

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (1) Apoptosis (6) ATP-binding cassette (ABC) transporters (1) Bacterial (2) Bcl-2 Family (2) Biochemical Assay Reagents (1) Caspase (2) COX (10) Endogenous Metabolite (1) Fungal (3) HDAC (1) IAP (1) Interleukin Related (10) JAK (2) Keap1-Nrf2 (3) Lipoxygenase (2) LXR (1) Mitochondrial Metabolism (1) Na+/H+ Exchanger (NHE) (1) nAChR (2) NF-κB (11) NO Synthase (22) NOD-like Receptor (NLR) (1) p38 MAPK (2) Parasite (1) PGE synthase (1) Phosphodiesterase (PDE) (1) PPAR (2) Prostaglandin Receptor (3) PROTACs (1) Reactive Oxygen Species (ROS) (4) Reference Standards (3) SARS-CoV (1) STAT (3) Survivin (1) TNF Receptor (8) Toll-like Receptor (TLR) (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (42) Metabolic Disease (5) Neurological Disease (4)

By Targets:

Akt (1)

Antibiotic (1)

Apoptosis (6)

ATP-binding cassette (ABC) transporters (1)

Bacterial (2)

Bcl-2 Family (2)

Biochemical Assay Reagents (1)

Caspase (2)

COX (10)

Endogenous Metabolite (1)

Fungal (3)

HDAC (1)

IAP (1)

Interleukin Related (10)

JAK (2)

Keap1-Nrf2 (3)

Lipoxygenase (2)

LXR (1)

Mitochondrial Metabolism (1)

Na+/H+ Exchanger (NHE) (1)

nAChR (2)

NF-κB (11)

NO Synthase (22)

NOD-like Receptor (NLR) (1)

p38 MAPK (2)

Parasite (1)

PGE synthase (1)

Phosphodiesterase (PDE) (1)

PPAR (2)

Prostaglandin Receptor (3)

PROTACs (1)

Reactive Oxygen Species (ROS) (4)

Reference Standards (3)

SARS-CoV (1)

STAT (3)

Survivin (1)

TNF Receptor (8)

Toll-like Receptor (TLR) (1)

VEGFR (1)

Virus Protease (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (1)

Infection (4)

Inflammation/Immunology (42)

Metabolic Disease (5)

Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0569

Madecassic acid 2 Publications Verification	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-N3383

Ligustroside Ligstroside	Mitochondrial Metabolism	Neurological Disease
Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages .

HY-129113

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N2535

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-W082785A

L6H21 1 Publications Verification	TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K_D value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC₅₀ values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .

HY-146066

α7 nAchR-JAK2-STAT3 agonist 1	nAChR JAK STAT NO Synthase Interleukin Related	Inflammation/Immunology
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .

HY-125531

Dactylorhin A	Others	Others
Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells .

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .

HY-146346

HD-TAC7	PROTACs HDAC	Inflammation/Immunology
HD-TAC7 is a potent PROTAC HDAC degrader with IC₅₀ values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 can decreases NF-κB p65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD) .

HY-N7012

7,3',4'-Tri-O-methylluteolin 1 Publications Verification 5-Hydroxy-3',4',7-trimethoxyflavone	Lipoxygenase TNF Receptor Interleukin Related COX Fungal Parasite Apoptosis	Infection Inflammation/Immunology Cancer
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC₅₀ value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities sup>[4]sup>[5].

HY-N3001

Isolinderalactone 1 Publications Verification	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase	Neurological Disease Inflammation/Immunology Cancer
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-N0569R

Madecassic acid (Standard) 2 Publications Verification	Reference Standards NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid (Standard) is the analytical standard of Madecassic acid. This product is intended for research and analytical applications. Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-168336

E0924G	PPAR	Metabolic Disease
E0924G is an orally active activator for PPARδ with EC₅₀ of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC₅₀ of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models .

HY-N8160

Dehydrocurdione	Keap1-Nrf2 Reactive Oxygen Species (ROS)	Inflammation/Immunology
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .

HY-W201317

E17241	PPAR	Metabolic Disease
E17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs ). E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet .

HY-169859

EP4 receptor antagonist 7	Prostaglandin Receptor Interleukin Related	Inflammation/Immunology Cancer
EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC₅₀ value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC₅₀ value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD ⁸⁺ T cells into tumors in a CT26 murine colon cancer model .

HY-146066A

(R)-α7 nAchR-JAK2-STAT3 agonist 1	nAChR JAK STAT NO Synthase	Others
(R)-α7 nAchR-JAK2-STAT3 agonist 1 is the R-enantiomer of α7 nAchR-JAK2-STAT3 agonist 1 (HY-146066). α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N12283

NF-κB-IN-13	NF-κB	Inflammation/Immunology
NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .

HY-N7422

Kauran-16,17-diol ent-Kauran-16β,17-diol	Apoptosis	Inflammation/Immunology Cancer
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .

HY-N17239

Oleracone	TNF Receptor Interleukin Related NO Synthase	Inflammation/Immunology
Oleracone is a type of alkaloid that can be found in Portulaca oleracea L.. Oleracone exhibits a significant anti-inflammatory effect in the RAW 264.7 macrophage model induced by LPS (HY-D1056), capable of inhibiting NO production and significantly suppressing the secretion of pro-inflammatory cytokines TNF-α, IL-6, and prostaglandin E₂ (PGE₂). Oleracone can be used for the study of inflammatory diseases .

HY-129113R

α-?Chaconine (Standard)	Reference Standards COX	Inflammation/Immunology
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase	Inflammation/Immunology
1,3,5-Trihydroxy-4-prenylxanthone is a Na ⁺/H ⁺ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-N10114

Hyperectumine	Others	Inflammation/Immunology
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-N10297

Curindolizine	Others	Inflammation/Immunology
Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC₅₀ value of 5.31 μM .

HY-N10865

Chloranthalactone E	NO Synthase	Inflammation/Immunology
Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages .

HY-N11548

Inflexuside A	NO Synthase	Inflammation/Immunology
Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages .

HY-N11544

Inflexuside B	NO Synthase	Inflammation/Immunology
Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages .

HY-N11570

Phaeocaulisin E	Others	Inflammation/Immunology
Phaeocaulisin E (Compound 5) is a guaiane-type sesquiterpene that inhibits LPS HY-(HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC₅₀ of 10.3 μM .

HY-N13138

Angulasaponin B	NO Synthase	Inflammation/Immunology
Angulasaponin B, a natural product, can be obtained from Vigna angularis. Angulasaponin B inhibits nitric oxide production in LPS-activated RAW264.7 macrophages with IC₅₀ values ranging from 13 μM to 24 μM .

HY-124508

Lambertellin	Antibiotic Bacterial Fungal p38 MAPK NF-κB	Infection Inflammation/Immunology
Lambertellin is an effective antibiotic that can be used as a bactericide and as a fungicide. Lambertellin exerts its anti-inflammatory effect in LPS (HY-D1056)-stimulated RAW 264.7 macrophage cells by modulating the activation of the MAPK and NF-κB signaling pathways .

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-153762

COX-2-IN-32	NO Synthase NF-κB COX	Inflammation/Immunology
COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC₅₀: 11.2 μM) .

HY-N3289A

(E)-Methyl 3,4,5-trimethoxycinnamate	Others	Inflammation/Immunology
(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes .

HY-115780

E17110	LXR ATP-binding cassette (ABC) transporters	Cardiovascular Disease
E17110 is a liver X receptor β (LXRβ) agonist with an EC₅₀ of 0.72 μM. E17110 can increase the expression of ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 macrophages. E17110 also reduce cellular lipid accumulation and promoted cholesterol efflux. E17110 can be used for the research of cardiovascular disease, such as atherosclerosis .

HY-163355

COX-2/15-LOX-IN-5	COX Lipoxygenase NF-κB	Inflammation/Immunology
COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities .

HY-131626

1a,1b-Dihomo prostaglandin E2 1a,1b-Dihomo PGE2	COX	Metabolic Disease
1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.

HY-169974

SARS-CoV-2-IN-107	SARS-CoV Virus Protease NO Synthase	Infection Inflammation/Immunology
SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC₅₀ of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC₅₀ of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages .

HY-N2535R

Coniferaldehyde (Standard) 4-Hydroxy-3-methoxycinnamaldehyde (Standard)	Reference Standards Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-155821

Anti-inflammatory agent 55	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-155820

Anti-inflammatory agent 54	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-N12087

8-Deoxylactucin	NF-κB NO Synthase Reactive Oxygen Species (ROS)	Inflammation/Immunology
8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages with an IC₅₀ value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries .

HY-158402

Anti-inflammatory agent 84	Bacterial Fungal	Infection Inflammation/Immunology
Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC₅₀ of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .

HY-W587743

N1-Acetyl-5-methoxykynuramine hydrochloride AMK hydrochloride	Prostaglandin Receptor PGE synthase COX Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease
N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin (HY-B0075). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinson's disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases

HY-N15221

12-Acetoxyganoderic acid D	NO Synthase	Inflammation/Immunology
12-Acetoxyganoderic acid D is a triterpenoid compound found in Ganoderma sinense. 12-Acetoxyganoderic acid D exhibits certain anti-inflammatory activity and inhibits NO production in LPS (HY-D1056) stimulated RAW 264.7 macrophages .

HY-N16677

Abiesadine I	NO Synthase	Inflammation/Immunology
Abiesadine I is a diterpenoid inhibitor targeting LPS-induced NO production (IC₅₀>100 μg/mL) that can be isolated from Abies georgei. Abiesadine I inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, exhibiting anti-inflammatory activity .

HY-N1192

Sutherlandin trans-p-coumarate	NO Synthase	Inflammation/Immunology
Sutherlandin trans-p-coumarate is a selective γ-hydroxynitrile glycoside compound with moderate inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages (56.9% inhibition at a concentration of 25 μg/mL). Sutherlandin trans-p-coumarate can be naturally extracted from the dried aerial parts of Sorbaria sorbifolia (a plant of the genus Sorbaria in the Rosaceae family) .

HY-N16774

Balanophonin B	NO Synthase	Inflammation/Immunology
Balanophonin B is a selective inhibitor (IC₅₀=1.46 μg/mL) that targets the lipopolysaccharide (LPS)-induced nitric oxide (NO) production pathway and can be isolated from Lithocarpus pachylepis. Balanophonin B inhibits the production of NO in LPS-stimulated RAW264.7 macrophages and exerts anti-inflammatory activity to reduce the inflammatory response. Balanophonin B can be used for anti-inflammatory drug development and biological activity research of natural lignan compounds .

HY-N18025

Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside	NF-κB p38 MAPK Akt Prostaglandin Receptor TNF Receptor Interleukin Related NO Synthase COX	Inflammation/Immunology
Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside is an anti-inflammatory agent. Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside exerts significant anti-inflammatory effects in LPS (HY-D1056)-induced RAW 264.7 macrophages by inhibiting the NF-κB, MAPK and Akt signaling pathways, thereby reducing the production of inflammatory mediators (NO, PGE2) and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) .

HY-N16817

Rabdoternin E	NO Synthase	Inflammation/Immunology Cancer
Rabdoternin E is a potential anti-inflammatory and antitumor agent. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages (IC₅₀=2.3 μM) and exhibits cytotoxicity against human tumor cells such as HL-60 and SW-480 (IC₅₀ values ??of 2.6 μM and 4.1 μM, respectively). Rabdoternin E is an ent-kaurane-type diterpenoid compound that can be naturally extracted from the 70% acetone aqueous extract of the aerial parts of Isodon rosthornii (Diels) Hara (a plant of the Lamiaceae family, Isodon genus) .

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