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Andropanolide 

Cat. No.: HY-N1912
Handling Instructions

Andrographolide (Andro) is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. Andrographolide is a bicyclic diterpenoid lactone mainly produced from the plant Andrographis (Andrographis paniculate). Andrographolide suppresses the activation of NF-κB in stimulated endothelial cells, which reduces the expression of cell adhesion molecule E-selectin and prevents E-selectin-mediated leukocyte adhesion, but has no effect on IκBα degradation, p50 and p65 nuclear translocation.

For research use only. We do not sell to patients.

Andropanolide Chemical Structure

Andropanolide Chemical Structure

CAS No. : 869807-57-8

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Estimated Time of Arrival: December 31
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Description

Andrographolide (Andro) is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. Andrographolide is a bicyclic diterpenoid lactone mainly produced from the plant Andrographis (Andrographis paniculate). Andrographolide suppresses the activation of NF-κB in stimulated endothelial cells, which reduces the expression of cell adhesion molecule E-selectin and prevents E-selectin-mediated leukocyte adhesion, but has no effect on IκBα degradation, p50 and p65 nuclear translocation[1].

In Vitro

Andrographolide (15 μM; 12 hours) inhibited the luciferase activities induced by TNF-α in a time-dependent manner with an IC50 of 10 μM[1].

Cell Proliferation Assay[1]

Cell Line: 293 cells
Concentration: 15 μM
Incubation Time: 12 hours
Result: Inhibited NF-κB activation induced by TNF-α.
Molecular Weight

350.45

Formula

C₂₀H₃₀O₅

CAS No.

869807-57-8

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Andropanolide
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HY-N1912
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