1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. Ligustroside

Ligustroside (Synonyms: Ligstroside)

Cat. No.: HY-N3383 Purity: ≥98.0%
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Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages.

For research use only. We do not sell to patients.

Ligustroside Chemical Structure

Ligustroside Chemical Structure

CAS No. : 35897-92-8

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1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages[1][2].

In Vitro

Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP695 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NMRI mice, aged 12 months[1]
Dosage: 50 mg/kg
Administration: Received a supplemented diet for 6 months (equivalent to 6.25 mg/kg b.w.)
Result: Showed improved spatial working memory; Restored brain ATP levels in aged mice and led to a significant life extension compared to aged control animals.
Molecular Weight

524.51

Formula

C25H32O12

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Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

References

Purity: ≥98.0%

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