Search Result

Results for "

analgesic and anti-pyretic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (17) Bacterial (10) Biochemical Assay Reagents (3) Carbamoyl Phosphate Synthetase (CPS) (2) COX (88) Cytochrome P450 (2) Drug Derivative (6) Drug Metabolite (13) Endogenous Metabolite (16) Environmental Pollutants (4) FAAH (1) Ferroptosis (2) Fluorescent Dye (4) Fungal (3) GABA Receptor (8) Histone Acetyltransferase (8) iGluR (7) Interleukin Related (8) Isotope-Labeled Compounds (29) Lipoxygenase (1) MMP (4) Monoamine Oxidase (2) NF-κB (4) NO Synthase (1) P2Y Receptor (1) p38 MAPK (2) Parasite (6) PERK (2) PGE synthase (4) Potassium Channel (8) Prostaglandin Receptor (6) Reactive Oxygen Species (ROS) (6) Reference Standards (43) Sex Pheromone (3) Thyroid Hormone Receptor (2) TNF Receptor (8) Tyrosinase (2) UGT (1) Urea Transporter (2)
By Research Areas:	Cancer (37) Cardiovascular Disease (7) Endocrinology (5) Infection (12) Inflammation/Immunology (144) Metabolic Disease (8) Neurological Disease (39)

By Targets:

5-HT Receptor (1)

Apoptosis (17)

Bacterial (10)

Biochemical Assay Reagents (3)

Carbamoyl Phosphate Synthetase (CPS) (2)

COX (88)

Cytochrome P450 (2)

Drug Derivative (6)

Drug Metabolite (13)

Endogenous Metabolite (16)

Environmental Pollutants (4)

FAAH (1)

Ferroptosis (2)

Fluorescent Dye (4)

Fungal (3)

GABA Receptor (8)

Histone Acetyltransferase (8)

iGluR (7)

Interleukin Related (8)

Isotope-Labeled Compounds (29)

Lipoxygenase (1)

MMP (4)

Monoamine Oxidase (2)

NF-κB (4)

NO Synthase (1)

P2Y Receptor (1)

p38 MAPK (2)

Parasite (6)

PERK (2)

PGE synthase (4)

Potassium Channel (8)

Prostaglandin Receptor (6)

Reactive Oxygen Species (ROS) (6)

Reference Standards (43)

Sex Pheromone (3)

Thyroid Hormone Receptor (2)

TNF Receptor (8)

Tyrosinase (2)

UGT (1)

Urea Transporter (2)

By Research Areas:

Cancer (37)

Cardiovascular Disease (7)

Endocrinology (5)

Infection (12)

Inflammation/Immunology (144)

Metabolic Disease (8)

Neurological Disease (39)

168

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0517

Erianin 10+ Cited Publications	Bacterial	Neurological Disease Cancer
Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

HY-B0476

Phenacetin 1 Publications Verification Acetophenetidin	COX	Inflammation/Immunology
Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-B0171

Antipyrine 3 Publications Verification Phenazone; Phenazon	Fluorescent Dye GABA Receptor	Metabolic Disease Inflammation/Immunology
Antipyrine (Phenazone) is an orally active antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine also delays gastric emptying (GE) in rats .

HY-B0363

Nimesulide 5+ Cited Publications R805	COX	Inflammation/Immunology Cancer
Nimesulide is a selective COX-2 inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-30235A

Benzydamine hydrochloride	PGE synthase Bacterial TNF Receptor	Inflammation/Immunology Cancer
Benzydamine hydrochloride is an orally administered prostaglandin synthesis inhibitor that has anti-inflammatory, analgesic, antipyretic, and antibacterial properties. Benzydamine hydrochloride can inhibit TNF-α, stabilize cell membranes, and reduce oxidative stress within cells .

HY-78131A

(S)-(+)-Ibuprofen Dexibuprofen	COX	Inflammation/Immunology Cancer
(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC₅₀s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects .

HY-B0811

Salicylamide 1 Publications Verification 2-Hydroxybenzamide	UGT	Inflammation/Immunology
Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent.

HY-B0578

Loxoprofen 1 Publications Verification	COX	Cardiovascular Disease Inflammation/Immunology Cancer
Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity .

HY-13913

NS-398 15+ Cited Publications	COX	Inflammation/Immunology Cancer
NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC₅₀ of 3.8 μM, and has no effect on COX-1 at 100 μM.

HY-N0564

Notopterol 2 Publications Verification	Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .

HY-B0578A

Loxoprofen sodium 1 Publications Verification	COX	Cardiovascular Disease Inflammation/Immunology Cancer
Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium can reduce atherosclerosis and shows antitumor activity .

HY-W040672

Ibufenac Dytransin	COX	Inflammation/Immunology
Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .

HY-135731

4-Methylamino antipyrine	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-118752

Fentiazac 1 Publications Verification	COX	Inflammation/Immunology
Fentiazac, alkanoic acid derivative, is an orally active non-steroidal anti-inflammatory agent, with analgesic, antipyretic and platelet anti-aggregation activity. Fentiazac can be used to research inflammatory diseases such as rheumatoid arthritis, osteoarthritis and tendinitis .

HY-13507

Lumiracoxib 1 Publications Verification COX-189	COX	Metabolic Disease Inflammation/Immunology Cancer
Lumiracoxib is a potent,selective and orally active COX-2 inhibitor with a K_i value of 0.06?μM . Lumiracoxib acts as a nonselective NSAID with?anti-inflammatory, analgesic and antipyretic activities. Lumiracoxib can be used for osteoarthritis and bone cancer research .

HY-B0440

Tenoxicam Ro-12-0068	COX	Inflammation/Immunology
Tenoxicam (Ro-12-0068), an antiinflammatory agent with analgesic and antipyretic properties.

HY-17361

Etofenamate	COX	Inflammation/Immunology
Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases .

HY-101432

Fenclozic acid ICI-54450; Acidum fenclozicum; Mialex	COX	Inflammation/Immunology
Fenclozic acid (ICI-54450) is an orally active anti-inflammatory, analgesic, and antipyretic agent. Fenclozic acid exhibits anti-inflammatory activity in Edadjuvant-induced arthritis and Carrageenin-induced oedema in rats. Fenclozic acid can be used for the research of arthritis .

HY-B1137

Ramifenazone Isopropylaminoantipyrine	Bacterial	Inflammation/Immunology
Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .

HY-B0171S

Antipyrine-d3 Phenazone-d₃; Phenazon-d₃	Isotope-Labeled Compounds	Inflammation/Immunology
Antipyrine-d₃ is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity .

HY-W009706

Alclofenac Allopydin; W-7320	Prostaglandin Receptor	Neurological Disease Inflammation/Immunology
Alclofenac (Allopydin) is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac irreversibly inhibits platelet aggregation. Alclofenac can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica .

HY-W176576

Falimint	Others	Neurological Disease Inflammation/Immunology
Falimint is an antipyretic and analgesic compound .

HY-N2399

Diffractaic acid	Apoptosis	Inflammation/Immunology Cancer
Diffractaic acid, a major constituent of U. longissimi, acts as an effective proapoptotic agent in various disorders research . Diffractaic acid is the analgesic and antipyretic component of Usnea diffracta .

$Diffractaic acid$

HY-107795

Benorilate 1 Publications Verification Salipran	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid. Benorylate has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis .

HY-N9929

Docosane 1 Publications Verification	Environmental Pollutants Biochemical Assay Reagents	Others
Docosane is a straight-chain alkane. Docosane can be used to synthesize structural composites with thermal energy storage/release capabilities. Docosane can also be used to prepare thermosensitive antipyretic analgesics .

HY-116070

Iodoantipyrine 4-Iodoantipyrine	Fluorescent Dye	Infection
Iodoantipyrine (4-Iodoantipyrine) is an iodinated Antipyrine (HY-B0171) with potential antiviral activity. Antipyrine (Phenazone) is an antipyretic and analgesic that also serves as a molecular probe of hepatic oxidative metabolites .

HY-114806

Fenclofenac Flenac; R 67408	Thyroid Hormone Receptor	Inflammation/Immunology
Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral LD₅₀ of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research .

HY-19384

Enflicoxib E 6087	COX	Inflammation/Immunology
Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).?Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models .

HY-B1054

Famprofazone	COX	Inflammation/Immunology
Famprofazone is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the pyrazolone series, and it has analgesic, anti-inflammatory, and antipyretic effects.

HY-66005S2

Acetaminophen-d7 Paracetamol-d₇; 4-Acetamidophenol-d₇; 4'-Hydroxyacetanilide-d₇	COX Endogenous Metabolite Histone Acetyltransferase	Inflammation/Immunology
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-B0476S

Phenacetin-d5 Acetophenetidin-d₅	COX	Inflammation/Immunology
Phenacetin-d₅ is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-B0578B

Loxoprofen sodium dihydrate	COX	Cardiovascular Disease Inflammation/Immunology Cancer
Loxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity .

HY-17476

Carbasalate calcium	Endogenous Metabolite	Inflammation/Immunology
Carbasalate calcium is an anti-inflammatory, antipyretic, and analgesic agent.

HY-133588

4-Formylaminoantipyrine	Endogenous Metabolite	Metabolic Disease
4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-W747297

β-Selinene	COX Endogenous Metabolite	Neurological Disease Inflammation/Immunology
β-Selinene is a sesquiterpene and is the main active component of the essential oil of red purple hibiscus (Callicarpa macrophylla). β-Selinene exhibits significant related antioxidant activity, anti-inflammatory activity, and antipyretic analgesic activity. β-Selinene may exert antioxidant effects by directly scavenging free radicals (DPPH, NO, •OH) and chelating pro-oxidative metal ions (Fe²⁺); inhibit cyclooxygenase (COX) activity, reduce prostaglandin (such as PGE₂) synthesis to exert anti-inflammatory effects; regulate the thermoregulatory set point of the hypothalamus and inhibit inflammatory mediators to exert antipyretic and analgesic effects .

HY-107795R

Benorilate (Standard) Salipran (Standard)	Reference Standards Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Benorilate (Standard) is the analytical standard of Benorilate. This product is intended for research and analytical applications. Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid. Benorylate has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis .

HY-W016034

Acetaminophen glucuronide sodium salt p-Acetamidophenyl β-D-glucuronide sodium salt; p-AAPG sodium salt	Drug Metabolite	Infection
Acetaminophen glucuronide is a safe and effective antipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liver and kidney .

HY-105808

Furobufen	Drug Derivative	Neurological Disease Inflammation/Immunology
Furobufen, an anti-inflammatory agent, produces antiarthritic, antipyretic effects. Furobufen has an analgesic effect in inflamed tissue .

HY-B1015

Etosalamide Ethosalamide	Others	Inflammation/Immunology
Etosalamide (Ethosalamide) is an *antipyretic* and analgesic agent. Etosalamide has anti-inflammatory activity and can be used for allergic disease research .

HY-B1179

Dipyrocetyl	COX NF-κB	Neurological Disease Inflammation/Immunology
Dipyrocetyl is a Salicylic Acid (HY-B0167) derivative, exhibiting analgesic and antipyretic activity. Dipyrocetyl can be used for inflammation diseases and pain .

HY-17479BS

Amfenac-d5 sodium	Isotope-Labeled Compounds	Others
Amfenac-d₅ sodium is deuterated-labeled Amfenac sodium. Amfenac Sodium is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac Sodium can be used for the research of acute and chronic inflammation .

HY-17479S

Amfenac-d5	Isotope-Labeled Compounds	Others
Amfenac-d₅ is the deuterium labeled Amfenac. Amfenac is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac can be used for the research of acute and chronic inflammation .

HY-135731A

4-Methylamino antipyrine hydrochloride	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-B0811R

Salicylamide (Standard) 2-Hydroxybenzamide (Standard)	Reference Standards Others	Inflammation/Immunology
Salicylamide (Standard) is the analytical standard of Salicylamide. This product is intended for research and analytical applications. Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent.

HY-17491

Proquazone RU 43-715; Sandoz-43-715	Others	Inflammation/Immunology
Proquazone (RU 43-715) is a chemically distinctive non-steroidal anti-inflammatory agent (NSAID). unlike most other NSAIDs, Proquazone does not have a free acid group in its structure. Proquazone may inhibit or arrest progression of bone erosions. Proquazone is an orally active anti-inflammatory, analgesic and anti-pyretic agent .

HY-106823

Tebufelone NE-11740	COX Lipoxygenase	Neurological Disease Inflammation/Immunology
Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties .

HY-121132

Butibufen	Carbamoyl Phosphate Synthetase (CPS) Urea Transporter	Inflammation/Immunology
Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation .

HY-B1279AS

Metamizole-d3 sodium Dipyrone-d3; Methamizole-d3 sodium	Isotope-Labeled Compounds COX	Neurological Disease Inflammation/Immunology
Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a cyclooxygenase-3 (COX-3) inhibitor .

HY-135325

4-Hydroxyacetophenone oxime	Drug Metabolite	Inflammation/Immunology
4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic agent .

HY-30235

Benzydamine	PGE synthase TNF Receptor Bacterial	Inflammation/Immunology Cancer
Benzydamine is an orally administered prostaglandin synthesis inhibitor that has anti-inflammatory, analgesic, antipyretic, and antibacterial properties. Benzydamine can inhibit TNF-α, stabilize cell membranes, and reduce oxidative stress within cells .

Cat. No.	Product Name

HY-L130

Non-steroidal Anti-Inflammatory Compound Library

629 compounds

Non-steroidal anti-inflammatory drugs (NSAIDs) are members of a therapeutic drug class with potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. The most prominent NSAIDs are aspirin, ibuprofen, and naproxen.

The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX), based on which NSAIDs can be classified into two types: non-selective and COX-2 selective. Most NSAIDs are non-selective and inhibit both COX-1 and COX-2 activity.

MCE offers a unique collection of 629 non-steroidal compounds with identified anti-inflammatory activity. MCE non-steroidal anti-inflammatory library is a useful tool for the study of anti-inflammatory drugs and pharmacology.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-66005

Acetaminophen Maximum Cited Publications 70 Publications Verification Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite COX Histone Acetyltransferase Parasite Bacterial Ferroptosis
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .

HY-N0517

Erianin 10+ Cited Publications	Structural Classification Monophenols Orchidaceae Phenols Plants Dendrobium nobile Lindl. Source Classification	Bacterial
Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

HY-B0811

Salicylamide 1 Publications Verification 2-Hydroxybenzamide	Alkaloids Monophenols Microorganisms Classification of Application Fields Other Alkaloids Phenols Inflammation/Immunology Disease Research Fields Source Classification	UGT
Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent.

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both COX-1 and COX-2 (COX-1: IC₅₀=0.005 μM; COX-2:IC₅₀=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .

HY-N0564

Notopterol 2 Publications Verification	Neurological Disease Classification of Application Fields Coumarins Phenylpropanoids Kleinia odora (Forssk.) DC. Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .

HY-W089845

Heneicosane 1 Publications Verification	Infection Structural Classification Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification	Environmental Pollutants Fungal Sex Pheromone
Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs .

HY-N7926

Pentadecane	Structural Classification Natural Products Kaempferia galanga L. Plants Source Classification Zingiberaceae	Environmental Pollutants Apoptosis Parasite TNF Receptor Interleukin Related
Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-N2399

Diffractaic acid	Monophenols Classification of Application Fields Usnea diffracta Vain. Ketones, Aldehydes, Acids Phenols Plants Disease Research Fields Inflammation/Immunology Usneaceae Source Classification	Apoptosis
Diffractaic acid, a major constituent of U. longissimi, acts as an effective proapoptotic agent in various disorders research . Diffractaic acid is the analgesic and antipyretic component of Usnea diffracta .

$Diffractaic acid$

HY-N9929

Docosane 1 Publications Verification	Structural Classification Natural Products Frullania Classification of Application Fields Frullaniaceae Other Diseases Plants Disease Research Fields Source Classification	Environmental Pollutants Biochemical Assay Reagents
Docosane is a straight-chain alkane. Docosane can be used to synthesize structural composites with thermal energy storage/release capabilities. Docosane can also be used to prepare thermosensitive antipyretic analgesics .

HY-133588

4-Formylaminoantipyrine	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-W747297

β-Selinene	Other Terpenoids Structural Classification Terpenoids Psidium guajava Linn. Myrtaceae Plants Source Classification	COX Endogenous Metabolite
β-Selinene is a sesquiterpene and is the main active component of the essential oil of red purple hibiscus (Callicarpa macrophylla). β-Selinene exhibits significant related antioxidant activity, anti-inflammatory activity, and antipyretic analgesic activity. β-Selinene may exert antioxidant effects by directly scavenging free radicals (DPPH, NO, •OH) and chelating pro-oxidative metal ions (Fe²⁺); inhibit cyclooxygenase (COX) activity, reduce prostaglandin (such as PGE₂) synthesis to exert anti-inflammatory effects; regulate the thermoregulatory set point of the hypothalamus and inhibit inflammatory mediators to exert antipyretic and analgesic effects .

HY-N1965

Gaultherin	other families Classification of Application Fields Ketones, Aldehydes, Acids Gaultheria yunnanensis Ericaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK COX Monoamine Oxidase MMP Interleukin Related TNF Receptor Reactive Oxygen Species (ROS)
Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, COX-2 (IC₅₀ = 0.35 mg/mL), LOX (IC₅₀ = 0.56 mg/mL) and HYAL (IC₅₀ = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) .

HY-B0811R

Salicylamide (Standard) 2-Hydroxybenzamide (Standard)	Alkaloids Monophenols Microorganisms Other Alkaloids Phenols Source Classification	Reference Standards Others
Salicylamide (Standard) is the analytical standard of Salicylamide. This product is intended for research and analytical applications. Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent.

HY-119413R

9-Ethyladenine (Standard)	Natural Products Microorganisms Source Classification	Reference Standards Endogenous Metabolite
Loxoprofen (sodium) (Standard) is the analytical standard of Loxoprofen (sodium). This product is intended for research and analytical applications. Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium can reduce atherosclerosis and shows antitumor activity .

HY-N0517R

Erianin (Standard)	Structural Classification Natural Products Monophenols Orchidaceae Phenols Plants Dendrobium nobile Lindl. Source Classification	Reference Standards Bacterial
Erianin (Standard) is the analytical standard of Erianin. This product is intended for research and analytical applications. Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

HY-N0564R

Notopterol (Standard)	Structural Classification Coumarins Phenylpropanoids Kleinia odora (Forssk.) DC. Umbelliferae Plants Source Classification	Reference Standards Apoptosis
Notopterol (Standard) is the analytical standard of Notopterol. This product is intended for research and analytical applications. Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .

HY-N7514

Strictosidinic acid	Alkaloids other families Plants Indole Alkaloids Source Classification	5-HT Receptor
Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice .

HY-123100R

Ganoderic acid N (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Endogenous metabolite Source Classification	Reference Standards Others
Isoxepac (Standard) is the analytical standard of Isoxepac. This product is intended for research and analytical applications. Isoxepac (HP 549) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory, analgesic and antipyretic activity. Isoxepac has been studied in rat, rabbit, dog, rhesus monkey, etc .

HY-N9929R

Docosane (Standard)	Structural Classification Natural Products Frullania Frullaniaceae Plants Source Classification	Reference Standards Biochemical Assay Reagents
Docosane (Standard) is the analytical standard of Docosane (HY-N9929). This product is intended for research and analytical applications. Docosane is a straight-chain alkane. Docosane can be used to synthesize structural composites with thermal energy storage/release capabilities. Docosane can also be used to prepare thermosensitive antipyretic analgesics .

HY-N1965R

Gaultherin (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Gaultheria yunnanensis Ericaceae Plants Source Classification	Reference Standards NF-κB p38 MAPK COX Reactive Oxygen Species (ROS) Monoamine Oxidase MMP Interleukin Related TNF Receptor
Gaultherin (Standard) is the analytical standard for Gaultherin (HY-N1965). Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, COX-2 (IC₅₀ = 0.35 mg/mL), LOX (IC₅₀ = 0.56 mg/mL) and HYAL (IC₅₀ = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) .

HY-N7926R

Pentadecane (Standard)	Structural Classification Natural Products Kaempferia galanga L. Plants Source Classification Zingiberaceae	Parasite Reference Standards TNF Receptor Interleukin Related Apoptosis
Pentadecane (Standard) is the analytical standard of Pentadecane (HY-N7926). This product is intended for research and analytical applications. Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-W089845R

Heneicosane (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Sex Pheromone Fungal
Heneicosane (Standard) is the analytical standard of Heneicosane (HY-W089845). This product is intended for research and analytical applications. Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs .

HY-N16663

Plantagiolide C	Structural Classification Natural Products Schizocapsa plantaginea Hance Plants Taccaceae Source Classification	Others
Plantagiolide C is a withanolide found in Tacca plantaginea. Tacca plantaginea has analgesic, antipyretic and anti-inflammatory effects .

HY-N18761

Willow bark extract	Structural Classification Extract	Others
Willow Bark Extract is derived from the branch or bark extract of weeping willow of the Salix family. It has antipyretic, analgesic, anti-inflammatory, and anti-rheumatic effects.

HY-N18743

Achyranthes aspera extract	Structural Classification Extract	Others
Achyranthes aspera extract is a versatile plant extract highly regarded for its many medicinal properties, including analgesic, anti-inflammatory, diuretic, antipyretic, and anthelmintic effects.

HY-133588R

4-Formylaminoantipyrine (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
4-Formylaminoantipyrine (Standard) is the analytical standard of 4-Formylaminoantipyrine. This product is intended for research and analytical applications. 4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

Cat. No.	Product Name	Chemical Structure

HY-66005S

Acetaminophen-d4
Acetaminophen-d₄ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B0171S

Antipyrine-d3
Antipyrine-d₃ is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity .

HY-66005S1

Acetaminophen-d3
Acetaminophen-d₃ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-66005S2

Acetaminophen-d7
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-B0476S

Phenacetin-d5
Phenacetin-d₅ is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-10582S

Flurbiprofen-d3

Flurbiprofen-d₃ is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-10582S1

Flurbiprofen-d5

Flurbiprofen-d₅ is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-66005S4

Acetaminophen-13C2,15N
Acetaminophen- ¹³C₂, ¹⁵N is the ¹³C and ¹⁵N labeled Acetaminophen . Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM;is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-17479BS

Amfenac-d5 sodium
Amfenac-d₅ sodium is deuterated-labeled Amfenac sodium. Amfenac Sodium is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac Sodium can be used for the research of acute and chronic inflammation .

HY-17479S

Amfenac-d5
Amfenac-d₅ is the deuterium labeled Amfenac. Amfenac is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac can be used for the research of acute and chronic inflammation .

HY-B0476S1

Phenacetin-13C
Phenacetin- ¹³C is the ¹³C labeled Phenacetin . Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-78131AS

(S)-(+)-Ibuprofen-d3
(S)-(+)-Ibuprofen-d₃ is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC₅₀s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects .

HY-B1279AS

Metamizole-d3 sodium
Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a cyclooxygenase-3 (COX-3) inhibitor .

HY-135731AS

4-Methylamino antipyrine-d3 hydrochloride

4-Methylamino antipyrine-d₃ (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-66005S3

Acetaminophen-13C6
Acetaminophen-13C6 (Paracetamol-13C6) is the 13C-labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B0578S

Loxoprofen-d4
Loxoprofen-d₄ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively .

HY-W654009

Loxoprofen-d3
Loxoprofen-d₃ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity .

HY-B0440S

Tenoxicam-d3
Tenoxicam-d₃ is the deuterium labeled Tenoxicam. Tenoxicam (Ro-12-0068), an antiinflammatory agent with analgesic and antipyretic properties.

HY-121046S

Flunixin-d3 1 Publications Verification
Flunixin-d₃ is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity .

HY-A0273S

Propyphenazone-d3
Propyphenazone-d₃ is the deuterium labeled Propyphenazone. Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as proagents and selective cyclooxygenase-2 inhibitors.

HY-B1137S

Ramifenazone-d7
Ramifenazone-d₇ is the deuterium labeled Ramifenazone. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .

HY-W702634

Butibufen-d5
Butibufen-d₅ is the deuterium labeled Butibufen (HY-121132). Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation .

HY-W741411

Tenoxicam-d4
Tenoxicam-d₄ (Ro-12-0068-d₄) is the deuterium labeled Tenoxicam (HY-B0440). Tenoxicam (Ro-12-0068), an antiinflammatory agent with analgesic and antipyretic properties.

HY-133588S

4-Formylaminoantipyrine-d3
4-Formylaminoantipyrine-d₃ is the deuterium labeled 4-Formylaminoantipyrine (HY-133588). 4-Formylaminoantipyrine is an excreted metabolite of Aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-N9929S

Docosane-d46
Docosane-d₄₆ is the deuterium labeled Docosane. Docosane is a straight-chain alkane. Docosane can be used to synthesize structural composites with thermal energy storage/release capabilities. Docosane can also be used to prepare thermosensitive antipyretic analgesics .

HY-17361S

Etofenamate-d4
Etofenamate-d₄ is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases .

HY-B0363S

Nimesulide-d5
Nimesulide-d₅ is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties .

HY-66005S5

Acetaminophen-d5
Acetaminophen-d₅ is deuterated-labeled Acetaminophen (HY-66005). Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B0363S1

Nimesulide-13C6
Nimesulide- ¹³C₆ (R805- ¹³C₆) is ¹³C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-W756637

Ibufenac-13C6
Ibufenac-13C6 (Dytransin-13C6) is the 13C-labeled Ibufenac (HY-W040672). Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .

HY-10582S3

Flurbiprofen-d4

Flurbiprofen-d₄ is deuterated labeled Flurbiprofen (HY-10582). Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-10582S2

Flurbiprofen-13C,d3

Flurbiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-W707708

N-(4-Ethoxyphenyl)acetamide-2,2,2-d3
N-(4-Ethoxyphenyl)acetamide-2,2,2-d₃ is the deuterium labeled Phenacetin (HY-B0476). Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-N7926S

Pentadecane-d32

Pentadecane-d₃₂ is the deuterium labeled Pentadecane (HY-N7926). Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-W089845S

Heneicosane-d44

Heneicosane-d₄₄ is the deuterium labeled Heneicosane (HY-W089845). Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs .

HY-B1398S

Ampyrone-d3

Ampyrone-d₃ is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .

HY-W701503

4-Methylamino antipyrine-d3-1

4-Methylamino antipyrine-d₃-1 is the deuterium labeled 4-Methylamino antipyrine-1. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-B0476S3

Phenacetin-13C-1
Phenacetin- ¹³C-1 (Acetophenetidin- ¹³C-1) is the ¹³C-labeled Phenacetin (HY-B0476). Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-W709349S

Flupirtine-d6 hydrochloride

Flupirtine-d₆ (D 9998-d₆) hydrochloride is the deuterium labeled Flupirtine hydrochloride (HY-W709349). Flupirtine hydrochloride is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine hydrochloride is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine hydrochloride stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine hydrochloride exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine hydrochloride functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine hydrochloride can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis .

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