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  3. Tenoxicam

Tenoxicam (Synonyms: Ro-12-0068)

Cat. No.: HY-B0440 Purity: 99.83%
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Tenoxicam (Ro-12-0068), an antiinflammatory agent with analgesic and antipyretic properties.

For research use only. We do not sell to patients.

Tenoxicam Chemical Structure

Tenoxicam Chemical Structure

CAS No. : 59804-37-4

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
500 mg USD 80 In-stock
Estimated Time of Arrival: December 31
1 g USD 120 In-stock
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5 g USD 576 In-stock
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Description

Tenoxicam (Ro-12-0068), an antiinflammatory agent with analgesic and antipyretic properties.

IC50 & Target[1][2]

COX-1

 

COX-2

 

In Vitro

Tenoxicam (Ro-12-0068) is a non-steroidal anti-inflammatory drug (NSAID)[1].

In Vivo

Tenoxicam (Ro-12-0068) was administered intraperitoneally immediately after BCAO. Histological analyses show that ischemia produced significant striatal as well as hippocampal lesions which were reversed by the Tenoxicam (Ro-12-0068) treatment. Tenoxicam (Ro-12-0068) also significantly reduced, to control levels, the increased myeloperoxidase activity in hippocampus homogenates observed after ischemia[2].

Clinical Trial
Molecular Weight

337.37

Formula

C₁₃H₁₁N₃O₄S₂

CAS No.

59804-37-4

SMILES

OC(C(SC=C1)=C1S2(=O)=O)=C(N2C)C(NC3=CC=CC=N3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (148.21 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9641 mL 14.8205 mL 29.6410 mL
5 mM 0.5928 mL 2.9641 mL 5.9282 mL
10 mM 0.2964 mL 1.4821 mL 2.9641 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.41 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TenoxicamRo-12-0068COXCyclooxygenaseInhibitorinhibitorinhibit

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Tenoxicam
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HY-B0440
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