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  3. Bacterial
  4. Erianin

Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

For research use only. We do not sell to patients.

Erianin Chemical Structure

Erianin Chemical Structure

CAS No. : 95041-90-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
1 mg USD 23 In-stock
5 mg USD 50 In-stock
10 mg USD 80 In-stock
50 mg USD 160 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Erianin Related Antibodies

Top Publications Citing Use of Products
Cell Viability Assay
Proliferation Assay
WB

    Erianin purchased from MedChemExpress. Usage Cited in: Nutr Cancer. 2023 Apr 26;1-12.  [Abstract]

    Erianin (15, 30, 60, 120, 240 nM; 48 h) suppresses the viability of various ESCC cells in a dose-dependent manner, especially the TE-10 and KYSE-150 cells.(TE-1, KYSE-30, KYSE-410, KYSE-150, and TE-10 cells belong to ESCC cells)

    Erianin purchased from MedChemExpress. Usage Cited in: Nutr Cancer. 2023 Apr 26;1-12.  [Abstract]

    Erianin (120 nM; 24 h) significantly inhibits the proliferation of TE-10 and KYSE-150 cells.

    Erianin purchased from MedChemExpress. Usage Cited in: Nutr Cancer. 2023 Apr 26;1-12.  [Abstract]

    Erianin (120 nM; 24 h) significantly inhibits the expression of vimentin, N-cadherin and β-catenin and increases the expression of E-cadherin in TE-10 and KYSE-150 cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis.

    In Vitro

    Erianin is often used as antipyretic and analgesic agent. Erianin belongs to bibenzyl derivatives in structure, with the activity of anti-virus, anti-bacterial, as well as anti-benign prostatic hyperplasia. Erianin has obvious damage on 2LL-IDO cells, Erianin basically has no cytotoxicity on human normal liver cell line L02, and cell viability is maintained at around 85%[1]. Erianin inhibits the growth of HeLa cells and induces apoptosis in a dose‑ and time‑dependent manner, inducing cell cycle arrest at the G2/M stage. Erianin treatment also increases the expression of Bax and caspase‑3, but decreases levels of Bcl‑2 and phosphorylated‑ERK1/2[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Erianin Related Antibodies
    Molecular Weight

    318.36

    Formula

    C18H22O5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1=CC(CCC2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (314.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1411 mL 15.7055 mL 31.4110 mL
    5 mM 0.6282 mL 3.1411 mL 6.2822 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Saline

      Solubility: 5 mg/mL (15.71 mM); Suspended solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (6.53 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 25 mg/mL (78.53 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.63%

    COA (247 KB) HNMR (256 KB) LCMS (87 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.1411 mL 15.7055 mL 31.4110 mL 78.5275 mL
    5 mM 0.6282 mL 3.1411 mL 6.2822 mL 15.7055 mL
    10 mM 0.3141 mL 1.5705 mL 3.1411 mL 7.8527 mL
    15 mM 0.2094 mL 1.0470 mL 2.0941 mL 5.2352 mL
    20 mM 0.1571 mL 0.7853 mL 1.5705 mL 3.9264 mL
    25 mM 0.1256 mL 0.6282 mL 1.2564 mL 3.1411 mL
    30 mM 0.1047 mL 0.5235 mL 1.0470 mL 2.6176 mL
    40 mM 0.0785 mL 0.3926 mL 0.7853 mL 1.9632 mL
    50 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5705 mL
    60 mM 0.0524 mL 0.2618 mL 0.5235 mL 1.3088 mL
    80 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9816 mL
    100 mM 0.0314 mL 0.1571 mL 0.3141 mL 0.7853 mL
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    Erianin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Erianin95041-90-0BacterialInhibitorinhibitorinhibit

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