Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers

  • Bioorg Med Chem Lett. 2001 Jan 8;11(1):51-4. doi: 10.1016/s0960-894x(00)00596-5.
N J Lawrence  1 ,  D Rennison ,  M Woo ,  A T McGown ,  J A Hadfield
Affiliations
PMID: 11140732 DOI: 10.1016/s0960-894x(00)00596-5
Abstract

A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for Anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.