2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Alclofenac (lysinate)

Alclofenac (lysinate)  (Synonyms: Allopydin (lysinate); W-7320 (lysinate))

Cat. No.: HY-W009706B
Handling Instructions Technical Support

Alclofenac (Allopydin) lysinate is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac lysinate irreversibly inhibits platelet aggregation. Alclofenac lysinate can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica.

For research use only. We do not sell to patients.

Alclofenac (lysinate)

Alclofenac (lysinate) Chemical Structure

CAS No. : 59960-34-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Alclofenac (lysinate):

Other Forms of Alclofenac (lysinate):

Alclofenac (lysinate) Related Antibodies

Top Publications Citing Use of Products

View All Prostaglandin Receptor Isoform Specific Products:

View All Isoforms
DP EP FP IP TXA2/TP TXB2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Alclofenac (Allopydin) lysinate is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac lysinate irreversibly inhibits platelet aggregation. Alclofenac lysinate can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica[1].

In Vitro

Alclofenac lysinate inhibits prostaglandin biosynthesis in vitro in ram seminal vesicle microsomes[1].
Alclofenac lysinate inhibits oxidative phosphorylation in rat liver mitochondria in vitro[1].
Alclofenac lysinate exerts cytostatic and cytotoxic effects on mammalian cells in vitro[1].
Alclofenac lysinate inhibits collagen- or epinephrine-induced human platelet aggregation in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alclofenac (lysinate) Related Antibodies
In Vivo

Alclofenac (20-100 mg/kg; p.o./s.c.) lysinate exhibits dose-dependent anti-inflammatory activity against carrageenan-induced paw edema in rats[1].
Alclofenac (25-100 mg/kg; p.o./s.c.) lysinate prevents and treats adjuvant-induced arthritis in rats[1].
Alclofenac lysinate exhibits analgesic activity in rats[1].
Alclofenac (100-200 mg/kg; p.o.) lysinate exerts a dose-dependent antipyretic effect in febrile rabbits[1].
Alclofenac (100-200 mg/kg; p.o./i.p.) lysinate exerts central nervous system depressant activity in rats, which is manifested by prolonged pentobarbital-induced sleep time[1].
Alclofenac (10-960 mg/kg; p.o.; once daily; for 5 consecutive days) lysinate inhibits acute inflammation in rats in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Carrageenin-induced paw oedema in rats[1]
Dosage: 20 mg/kg (p.o.); 40 mg/kg (p.o.); 80 mg/kg (p.o.); 25 mg/kg (s.c.); 100 mg/kg (s.c.)
Administration: p.o.; s.c.
Result: Slightly, but not significantly, suppressed carrageenin-induced paw oedema more effectively than equal doses of Phenylbutazone (HY-B0230) at oral doses of 20, 40, and 80 mg/kg.
Showed activity not significantly different from equal doses of Phenylbutazone at subcutaneous doses of 25 and 100 mg/kg.
Demonstrated effect independent of intact adrenals.
Molecular Weight

372.84

Formula

C17H25ClN2O5
CAS No.
SMILES

N[C@@H](CCCCN)C(O)=O.O=C(O)CC1=CC=C(OCC=C)C(Cl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Alclofenac (lysinate) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alclofenac (lysinate)59960-34-8Allopydin (lysinate) W-7320 (lysinate)Prostaglandin Receptornon-steroidal anti-inflammatory agentNSAIDanalgesicanti-inflammatoryand anti-pyretic propertiesprostaglandin H2 synthaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Alclofenac (lysinate)
Cat. No.:
HY-W009706B
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.