Alclofenac (lysinate)
Alclofenac (Allopydin) lysinate is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac lysinate irreversibly inhibits platelet aggregation. Alclofenac lysinate can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica.
For research use only. We do not sell to patients.
- CAS No.: 59960-34-8
- Formula: C17H25ClN2O5
- Molecular Weight:372.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Alclofenac lysinate inhibits prostaglandin biosynthesis in vitro in ram seminal vesicle microsomes[1].
Alclofenac lysinate inhibits oxidative phosphorylation in rat liver mitochondria in vitro[1].
Alclofenac lysinate exerts cytostatic and cytotoxic effects on mammalian cells in vitro[1].
Alclofenac lysinate inhibits collagen- or epinephrine-induced human platelet aggregation in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Alclofenac (25-100 mg/kg; p.o./s.c.) lysinate prevents and treats adjuvant-induced arthritis in rats[1].
Alclofenac lysinate exhibits analgesic activity in rats[1].
Alclofenac (100-200 mg/kg; p.o.) lysinate exerts a dose-dependent antipyretic effect in febrile rabbits[1].
Alclofenac (100-200 mg/kg; p.o./i.p.) lysinate exerts central nervous system depressant activity in rats, which is manifested by prolonged pentobarbital-induced sleep time[1].
Alclofenac (10-960 mg/kg; p.o.; once daily; for 5 consecutive days) lysinate inhibits acute inflammation in rats in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Carrageenin-induced paw oedema in rats[1]
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Dosage:20 mg/kg (p.o.); 40 mg/kg (p.o.); 80 mg/kg (p.o.); 25 mg/kg (s.c.); 100 mg/kg (s.c.)
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Administration:p.o.; s.c.
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Result:Slightly, but not significantly, suppressed carrageenin-induced paw oedema more effectively than equal doses of Phenylbutazone (HY-B0230) at oral doses of 20, 40, and 80 mg/kg.
Showed activity not significantly different from equal doses of Phenylbutazone at subcutaneous doses of 25 and 100 mg/kg.
Demonstrated effect independent of intact adrenals.
Chemical Information
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CAS No. 59960-34-8
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Molecular Weight 372.84
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Formula C17H25ClN2O5
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SMILES
N[C@@H](CCCCN)C(O)=O.O=C(O)CC1=CC=C(OCC=C)C(Cl)=C1
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Synonyms
Allopydin (lysinate); W-7320 (lysinate)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. R N Brogden, et al. Alclofenac: a review of its pharmacological properties and therapeutic efficacy in rheumatoid arthritis and allied rheumatic disorders. Drugs. 1977 Oct;14(4):241-59. [Content Brief]
[2]. Brogden RN, et al. Alclofenac: a review of its pharmacological properties and therapeutic efficacy in rheumatoid arthritis and allied rheumatic disorders. Drugs. 1977;14(4):241-259. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Alclofenac (lysinate) Related Classifications
HY-W009706B Related Classifications
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