Alclofenac sodium
Alclofenac (Allopydin) sodium is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac sodium irreversibly inhibits platelet aggregation. Alclofenac can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica.
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- CAS. Nr.: 24049-18-1
- Formel: C11H10ClNaO3
- Molecular Weight:248.64
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Alclofenac sodium inhibits prostaglandin biosynthesis in vitro in ram seminal vesicle microsomes[1].
Alclofenac sodium inhibits oxidative phosphorylation in rat liver mitochondria in vitro[1].
Alclofenac sodium exerts cytostatic and cytotoxic effects on mammalian cells in vitro[1].
Alclofenac sodium inhibits collagen- or epinephrine-induced human platelet aggregation in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Alclofenac (25-100 mg/kg; p.o./s.c.) sodium prevents and treats adjuvant-induced arthritis in rats[1].
Alclofenac exhibits analgesic activity in rats[1].
Alclofenac (100-200 mg/kg; p.o.) sodium exerts a dose-dependent antipyretic effect in febrile rabbits[1].
Alclofenac (100-200 mg/kg; p.o./i.p.) sodium exerts central nervous system depressant activity in rats, which is manifested by prolonged pentobarbital-induced sleep time[1].
Alclofenac (10-960 mg/kg; p.o.; once daily; for 5 consecutive days) sodium inhibits acute inflammation in rats in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Carrageenin-induced paw oedema in rats[1]
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Dosage:20 mg/kg (p.o.); 40 mg/kg (p.o.); 80 mg/kg (p.o.); 25 mg/kg (s.c.); 100 mg/kg (s.c.)
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Administration:p.o.; s.c.
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Result:Slightly, but not significantly, suppressed carrageenin-induced paw oedema more effectively than equal doses of Phenylbutazone (HY-B0230) at oral doses of 20, 40, and 80 mg/kg.
Showed activity not significantly different from equal doses of Phenylbutazone at subcutaneous doses of 25 and 100 mg/kg.
Demonstrated effect independent of intact adrenals.
Chemical Information
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CAS. Nr. 24049-18-1
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Molecular Weight 248.64
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Formel C11H10ClNaO3
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SMILES
O=C(O[Na])CC1=CC=C(OCC=C)C(Cl)=C1
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Synonyms
Allopydin sodium; W-7320 sodium
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. R N Brogden, et al. Alclofenac: a review of its pharmacological properties and therapeutic efficacy in rheumatoid arthritis and allied rheumatic disorders. Drugs. 1977 Oct;14(4):241-59. [Content Brief]
[2]. B S Selinsky, et al. Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry. 2001 May 1;40(17):5172-80. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Alclofenac sodium Related Classifications
HY-W009706A Related Classifications
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