2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Alclofenac sodium

Alclofenac sodium  (Synonyms: Allopydin sodium; W-7320 sodium)

Cat. No.: HY-W009706A
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Alclofenac (Allopydin) sodium is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac sodium irreversibly inhibits platelet aggregation. Alclofenac can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica.

For research use only. We do not sell to patients.

Alclofenac sodium

Alclofenac sodium Chemical Structure

CAS No. : 24049-18-1

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Alclofenac sodium Related Antibodies

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Description

Alclofenac (Allopydin) sodium is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac sodium irreversibly inhibits platelet aggregation. Alclofenac can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica[1].

In Vitro

Alclofenac sodium inhibits prostaglandin biosynthesis in vitro in ram seminal vesicle microsomes[1].
Alclofenac sodium inhibits oxidative phosphorylation in rat liver mitochondria in vitro[1].
Alclofenac sodium exerts cytostatic and cytotoxic effects on mammalian cells in vitro[1].
Alclofenac sodium inhibits collagen- or epinephrine-induced human platelet aggregation in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alclofenac sodium Related Antibodies
In Vivo

Alclofenac (20-100 mg/kg; p.o./s.c.) sodium exhibits dose-dependent anti-inflammatory activity against carrageenan-induced paw edema in rats[1].
Alclofenac (25-100 mg/kg; p.o./s.c.) sodium prevents and treats adjuvant-induced arthritis in rats[1].
Alclofenac exhibits analgesic activity in rats[1].
Alclofenac (100-200 mg/kg; p.o.) sodium exerts a dose-dependent antipyretic effect in febrile rabbits[1].
Alclofenac (100-200 mg/kg; p.o./i.p.) sodium exerts central nervous system depressant activity in rats, which is manifested by prolonged pentobarbital-induced sleep time[1].
Alclofenac (10-960 mg/kg; p.o.; once daily; for 5 consecutive days) sodium inhibits acute inflammation in rats in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Carrageenin-induced paw oedema in rats[1]
Dosage: 20 mg/kg (p.o.); 40 mg/kg (p.o.); 80 mg/kg (p.o.); 25 mg/kg (s.c.); 100 mg/kg (s.c.)
Administration: p.o.; s.c.
Result: Slightly, but not significantly, suppressed carrageenin-induced paw oedema more effectively than equal doses of Phenylbutazone (HY-B0230) at oral doses of 20, 40, and 80 mg/kg.
Showed activity not significantly different from equal doses of Phenylbutazone at subcutaneous doses of 25 and 100 mg/kg.
Demonstrated effect independent of intact adrenals.
Molecular Weight

248.64

Formula

C11H10ClNaO3
CAS No.
SMILES

O=C(O[Na])CC1=CC=C(OCC=C)C(Cl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Alclofenac sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alclofenac24049-18-1AllopydinW-7320W7320W 7320Prostaglandin Receptornon-steroidal anti-inflammatory agentNSAIDanalgesicanti-inflammatoryand anti-pyretic propertiesprostaglandin H2 synthaseInhibitorinhibitorinhibit

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