Phenopyrazone  (Synonyms: Diphenox; Kr 132)

Phenopyrazone (Diphenox), a derivative of Antipyrine (HY-B0171), exhibits oral activity as well as analgesic, antipyretic, anti-inflammatory, and antidiarrheal properties. Phenopyrazone can be used in research related to headache, rheumatism, chronic diarrhea and varicose veins^[1][2].

Phenopyrazone (p.o.; single dose; daily for 5 days) alone has minimal analgesic activity against Phenylquinone (HY-W275039)-induced writhing in mice, but significantly potentiates the analgesic activity of aminopyrine when co-administered or via prior daily treatment^[1].
Phenopyrazone (p.o.; single dose) alone has no detectable antipyretic activity against yeast-induced fever in rats at oral doses up to 640 mg/kg^[1].
Phenopyrazone (p.o.) exhibits anti-inflammatory activity against carrageenin-induced hind paw edema in rats with an ED₅₀ of 574.0 mg/kg p.o^[1].
Phenopyrazone (oral administration) serves as a component in preparations for venous disorders and induces pseudo‑lupus syndrome accompanied by high‑titer antimitochondrial antibodies^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

252.27

C₁₅H₁₂N₂O₂

3426-01-5

O=C1NN(C=2C=CC=CC2)C(=O)C1C=3C=CC=CC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nakamura H, et al. Combined Effect of Aminopyrine with Phenopyrazone on Analgesic, Anti-pyretic and Anti-inflammatory Activities in Experimental Animals. Yakugaku Zasshi, 1978, 98(6): 679-688.

  [2]. Verstraete M, et al. Drugs acting on the peripheral circulation. Side Effects of Drugs Annual, 1980, 4: 139-143.