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Cat. No.: HY-105592

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Phenopyrazone

(Synonyms: Diphenox; Kr 132)

Phenopyrazone (Diphenox), a derivative of Antipyrine (HY-B0171), exhibits oral activity as well as analgesic, antipyretic, anti-inflammatory, and antidiarrheal properties. Phenopyrazone can be used in research related to headache, rheumatism, chronic diarrhea and varicose veins.

For research use only. We do not sell to patients.

CAS No.: 3426-01-5
Formula: C₁₅H₁₂N₂O₂
Molecular Weight:252.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Phenopyrazone Chemical Structure

CAS No.: 3426-01-5

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vivo

Phenopyrazone (p.o.; single dose; daily for 5 days) alone has minimal analgesic activity against Phenylquinone (HY-W275039)-induced writhing in mice, but significantly potentiates the analgesic activity of aminopyrine when co-administered or via prior daily treatment^[1].
Phenopyrazone (p.o.; single dose) alone has no detectable antipyretic activity against yeast-induced fever in rats at oral doses up to 640 mg/kg^[1].
Phenopyrazone (p.o.) exhibits anti-inflammatory activity against carrageenin-induced hind paw edema in rats with an ED₅₀ of 574.0 mg/kg p.o^[1].
Phenopyrazone (oral administration) serves as a component in preparations for venous disorders and induces pseudo‑lupus syndrome accompanied by high‑titer antimitochondrial antibodies^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3426-01-5
Molecular Weight 252.27
Formula C₁₅H₁₂N₂O₂
SMILES

O=C1NN(C=2C=CC=CC2)C(=O)C1C=3C=CC=CC3
Synonyms

Diphenox; Kr 132
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nakamura H, et al. Combined Effect of Aminopyrine with Phenopyrazone on Analgesic, Anti-pyretic and Anti-inflammatory Activities in Experimental Animals. Yakugaku Zasshi, 1978, 98(6): 679-688.

[2]. Verstraete M, et al. Drugs acting on the peripheral circulation. Side Effects of Drugs Annual, 1980, 4: 139-143.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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