Varicose Veins

(R)-Efonidipine ((R)-NZ-105) is an orally active, selective T-type Ca²⁺ channel blocker. (R)-Efonidipine does not inhibit high-voltage-activated Ca²⁺ channels, voltage-dependent Na⁺ channels, or Ca²⁺-activated K⁺ channels. (R)-Efonidipine modulates cardiac autonomic function by increasing parasympathetic activity and decreasing sympathetic activity. (R)-Efonidipine significantly improves survival in a mouse model of dilated cardiomyopathy. (R)-Efonidipine can be used in research on ischemic encephalopathy, heart failure, and hypertension.

TRP-PK1 is a polypeptide. TRP-PK1 can be derived from the fourth transmembrane segment of TRPV4. TRP-PK1 can insert into the phospholipid bilayer. TRP-PK1 self-assembles to form K⁺-permeable channels, mediates K⁺ flux, hyperpolarizes the membrane potential of vascular smooth muscle, relaxes agonist-induced vasoconstriction, and lowers mean arterial pressure. TRP-PK1 enhances the tumor-targeting capability of cell membrane vesicles and displays Angiopep-2 (HY-P2341) on the surface of engineered vesicles. TRP-PK1 can be used for research on glioblastoma multiforme, head and neck cancer, and hypertension.

Phenopyrazone (Diphenox), a derivative of Antipyrine (HY-B0171), exhibits oral activity as well as analgesic, antipyretic, anti-inflammatory, and antidiarrheal properties. Phenopyrazone can be used in research related to headache, rheumatism, chronic diarrhea and varicose veins.