Cat. No.: HY-B1428

2-Ethoxybenzamide

(Synonyms: Ethenzamide)

Customer Review

Based on 1 Customer Validation

2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects. 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation. 2-Ethoxybenzamide can be used in the research of hypopigmentation and inflammation-related diseases.

For research use only. We do not sell to patients.

Purity: 99.82%
CAS No.: 938-73-8
Formula: C₉H₁₁NO₂
Molecular Weight:165.19

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

2-Ethoxybenzamide Chemical Structure

CAS No.: 938-73-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

2-Ethoxybenzamide (125-500 μM; 24-72 h) can increase the ROS level, enhance the expression of melanogenesis-related genes, and promote melanin synthesis in B16F1 murine melanoma cells. The mechanism involves the phosphorylation of ERK/CREB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

B16F1 melanoma cells
Concentration:

0, 125, 250 and 500 μM
Incubation Time:

72 h
Result:

Significantly increased the level of tyrosinase.
Slightly increased TRP-1 protein level and did not affect TRP-2 expression.

Chemical Information

CAS No. 938-73-8
Appearance Solid
Molecular Weight 165.19
Formula C₉H₁₁NO₂
Color White to off-white
SMILES

O=C(N)C1=CC=CC=C1OCC
Synonyms

Ethenzamide
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 47 mg/mL (284.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.0536 mL

30.2682 mL

60.5364 mL

5 mM

1.2107 mL

6.0536 mL

12.1073 mL

10 mM

0.6054 mL

3.0268 mL

6.0536 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kazuomi Sato, et al. 2-Ethoxybenzamide stimulates melanin synthesis in B16F1 melanoma cells via the CREB signaling pathway. Mol Cell Biochem. 2016 Dec;423(1-2):39-52. [Content Brief]

[2]. Srinivasulu Aitipamula, et al. Pharmaceutical cocrystals of ethenzamide: structural, solubility and dissolution studies. CrystEngComm, 2012,14, 8515-8524.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.0536 mL	30.2682 mL	60.5364 mL	151.3409 mL
	5 mM	1.2107 mL	6.0536 mL	12.1073 mL	30.2682 mL
	10 mM	0.6054 mL	3.0268 mL	6.0536 mL	15.1341 mL
	15 mM	0.4036 mL	2.0179 mL	4.0358 mL	10.0894 mL
	20 mM	0.3027 mL	1.5134 mL	3.0268 mL	7.5670 mL
	25 mM	0.2421 mL	1.2107 mL	2.4215 mL	6.0536 mL
	30 mM	0.2018 mL	1.0089 mL	2.0179 mL	5.0447 mL
	40 mM	0.1513 mL	0.7567 mL	1.5134 mL	3.7835 mL
	50 mM	0.1211 mL	0.6054 mL	1.2107 mL	3.0268 mL
	60 mM	0.1009 mL	0.5045 mL	1.0089 mL	2.5223 mL
	80 mM	0.0757 mL	0.3784 mL	0.7567 mL	1.8918 mL
	100 mM	0.0605 mL	0.3027 mL	0.6054 mL	1.5134 mL

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2-Ethoxybenzamide

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Anti-COVID-19 Compound Library

Endoplasmic Reticulum Stress Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Non-steroidal Anti-Inflammatory Compound Library

Pain-Related Compound Library

Off-patent Drug Library

Metabolic Enzyme Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

2-Ethoxybenzamide

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Anti-COVID-19 Compound Library

Endoplasmic Reticulum Stress Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Non-steroidal Anti-Inflammatory Compound Library

Pain-Related Compound Library

Off-patent Drug Library

Metabolic Enzyme Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

2-Ethoxybenzamide Related Classifications

HY-B1428 Related Classifications