COX-1-IN-5
COX-1-IN-5 (example 13, compound PS13) is a potent and selective COX-1 inhibitor (COX-1 IC50 = 1 nM, COX-2 IC50 > 0.1 μM) exhibiting >1000-fold selectivity over COX-2. COX-1-IN-5 possesses strong anti-inflammatory, antipyretic, analgesic, antithrombotic, anti-cancer activities. COX-1-IN-5 can be used for COX-mediated diseases research, such as inflammatory conditions and pain. COX-1-IN-5 radiolabeled with 11C can be used as a selective PET tracer for whole‑body imaging of COX‑1 distribution and target engagement in vivo.
For research use only. We do not sell to patients.
- CAS No.: 524699-85-2
- Formula: C18H16F3N3O3
- Molecular Weight:379.33
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
COX-1 1 nM (IC50) |
COX-2 >0.1 μM (IC50) |
Chemical Information
-
CAS No. 524699-85-2
-
Molecular Weight 379.33
-
Formula C18H16F3N3O3
-
SMILES
FC(F)(COC1=NN(C2=CC=C(C=C2)OC)C(C3=CC=C(OC)C=C3)=N1)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-1-IN-5 Related Classifications
HY-160184 Related Classifications
Powered by Bioz