524699-85-2
Chemical Structure
COX-1-IN-5
- CAS No.: 524699-85-2
- Formula:C18H16F3N3O3
- Molecular Weight:379.33
IUPAC Name: 1,5-bis(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazole
InChIKey: YBEGHAAVDAFSSE-UHFFFAOYSA-N
SMILES: FC(F)(COC1=NN(C2=CC=C(C=C2)OC)C(C3=CC=C(OC)C=C3)=N1)F
Biological Activity: COX-1-IN-5 (example 13, compound PS13) is a potent and selective COX-1 inhibitor (COX-1 IC50 = 1 nM, COX-2 IC50 > 0.1 μM) exhibiting >1000-fold selectivity over COX-2. COX-1-IN-5 possesses strong anti-inflammatory, antipyretic, analgesic, antithrombotic, anti-cancer activities. COX-1-IN-5 can be used for COX-mediated diseases research, such as inflammatory conditions and pain. COX-1-IN-5 radiolabeled with 11C can be used as a selective PET tracer for whole‑body imaging of COX‑1 distribution and target engagement in vivo[1][2].
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COX-1-IN-5 | COX-1-IN-5 (example 13, compound PS13) is a potent and selective COX-1 inhibitor (COX-1 IC50 = 1 nM, COX-2 IC50 > 0.1 μM) exhibiting >1000-fold selectivity over COX-2. COX-1-IN-5 possesses strong anti-inflammatory, antipyretic, analgesic, antithrombotic, anti-cancer activities. COX-1-IN-5 can be used for COX-mediated diseases research, such as inflammatory conditions and pain. COX-1-IN-5 radiolabeled with 11C can be used as a selective PET tracer for whole‑body imaging of COX‑1 distribution and target engagement in vivo. | |||||||||||||||||||||
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References
- [1]. Satoshi Aoki, et al. Triazole derivatives as cyclooxygenase (cox) inhibitors. WO2003040110A1. 2003-05-15.
- [2]. Kim MJ, et al. Whole-Body PET Imaging in Humans Shows That 11C-PS13 Is Selective for Cyclooxygenase-1 and Can Measure the In Vivo Potency of Nonsteroidal Antiinflammatory Drugs. J Nucl Med. 2023 Jan;64(1):159-164. [Content Brief]
