Search Result

Results for "

hydroxysteroid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (40) 17β-HSD (115) 3β-HSD (3) ADC Payload (1) Aldose Reductase (5) Amyloid-β (1) Androgen Receptor (6) Apoptosis (3) ATF6 (1) Autophagy (3) Bacterial (1) Biochemical Assay Reagents (5) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (16) Estrogen Receptor/ERR (5) Fungal (3) Glucocorticoid Receptor (1) HIV (1) Isotope-Labeled Compounds (6) Mineralocorticoid Receptor (1) OAT (1) Parasite (2) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (1) PROTACs (1) Reference Standards (5) Somatostatin Receptor (1) Steroid Sulfatase (4)
By Research Areas:	Cancer (27) Cardiovascular Disease (6) Endocrinology (16) Infection (6) Inflammation/Immunology (6) Metabolic Disease (142) Neurological Disease (11)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

200

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: 17β-HSD 11β-HSD

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113263

17a-Hydroxypregnenolone 2 Publications Verification 17-OHP5	Endogenous Metabolite	Metabolic Disease
17a-Hydroxypregnenolone (17-OHP5) is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .

HY-14598

Diethylstilbestrol 3 Publications Verification	Estrogen Receptor/ERR Apoptosis Autophagy	Endocrinology Cancer
Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a *11β-hydroxysteroid* dehydrogenase 2 (HSD11B2)** inhibitor. .

HY-125586

β-Amanitin	DNA/RNA Synthesis ADC Payload	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-148814

BI-3231 2 Publications Verification	17β-HSD	Metabolic Disease
BI 3231, a chemical probe, is a potent and selective hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) inhibitor, with IC₅₀s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases .

HY-114009

AKR1C1-IN-1 2 Publications Verification	Aldose Reductase	Neurological Disease
AKR1C1-IN-1 is a potent and selective inhibitor of *human 20α-hydroxysteroid* dehydrogenase (AKR1C1), with a K_i** value of 4 nM for AKR1C1 .

HY-P2901

*3α-Hydroxysteroid* Dehydrogenase, Microorganism** 3α-HSD	Endogenous Metabolite	Endocrinology
3α-Hydroxysteroid Dehydrogenase, Microorganism (3α-HSD) is an enzyme encoded by the AKR1C4 gene, which can catalyze the conversion of 3-ketosteroids into 3α-hydroxy compounds. 3α-Hydroxysteroid dehydrogenase plays an important role in the inactivation of androgen DHT, and can convert DHT into 3α-androstanediol with weak androgen activity, which can be used in the research of hirsutism .

HY-18056

PF-915275	11β-HSD	Metabolic Disease
PF-915275 is a potent, selective and orally active *human 11β-hydroxysteroid* dehydrogenase type 1 (11βHSD1) inhibitor with a K_i of 2.3 nM and an EC₅₀ of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC₅₀** of 20 and 100 nM, respectively .

HY-18055

BVT-14225 1 Publications Verification	11β-HSD	Metabolic Disease
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC₅₀ of 52 nM.

HY-18053

AZD 4017	11β-HSD	Metabolic Disease
AZD 4017 is a potent, selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) inhibitor, with an IC₅₀ of 7 nM.

HY-N2337

11beta-Hydroxyprogesterone 4 Publications Verification 11β-Hydroxyprogesterone	11β-HSD	Cardiovascular Disease
11beta-Hydroxyprogesterone is a potent inhibitors of *11β-Hydroxysteroid* dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀** of 10 nM.

HY-109619

D4-abiraterone Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite	Androgen Receptor Cytochrome P450	Cancer
D4-abiraterone is a major metabolite of abiraterone. D4-abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor.

HY-17462

Adrenosterone (+)-Adrenosterone	Androgen Receptor Endogenous Metabolite	Endocrinology Cancer
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-159525

Linustedastatum Linustedastat; FOR-6219; OG-6219	17β-HSD	Endocrinology
Linustedastatum (Linustedastat; FOR-6219) is an orally active hydroxysteroid 17-beta dehydrogenase 1 (HSD17B1) inhibitor. Linustedastatum can be used for the study of endometriosis .

HY-160618

11β-HSD2-IN-2	11β-HSD	Metabolic Disease
11β-HSD2-IN-2 (compound 3) is a selective inhibitor for 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) with an IC₅₀ of 300 nM .

HY-19325

SKI2852	11β-HSD	Metabolic Disease
SKI2852 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC₅₀s of 1.6 nM and 2.9 nM against mHSD1 and hHSD1, respectively .

HY-W011243

11alpha-Hydroxyprogesterone	11β-HSD	Cardiovascular Disease
11alpha-Hydroxyprogesterone is the analogue of 11beta-Hydroxyprogesterone (HY-N2337), and can be used as an experimental control. 11beta-Hydroxyprogesterone is a potent inhibitors of *11β-Hydroxysteroid* dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀** of 10 nM.

HY-123800

BI 187004 VTP-34072	11β-HSD	Neurological Disease
BI 187004 (VTP-34072) is an *11β-hydroxysteroid* dehydrogenase 1** inhibitor for use in diabetes research .

HY-105128

Epostane WIN 32729	3β-HSD	Endocrinology
Epostane (WIN 32729) is an orally active inhibitor for *3β-hydroxysteroid* dehydrogenase, with IC₅₀** of 1.45 nM. Epostane blocks ovulation and pregnancy in rats .

HY-W002734

(3-Hydroxyphenyl)boronic acid 3-Hydroxybenzeneboronic acid	Drug Intermediate	Endocrinology
(3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors .

HY-118819

5-Bromo-3-phenyl salicylic acid	Aldose Reductase	Neurological Disease Cancer
5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with K_i of 140 nM .

HY-103394

TC HSD 21	17β-HSD	Cancer
TC HSD 21 is a selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) against related 17β-HSD isozymes, with an IC₅₀ of 14 nM in HeLa cells. TC HSD 21 can be used in the research of prostate cancer .

HY-106447

Losulazine	Phosphatase 17β-HSD Dopamine Receptor	Cardiovascular Disease
Losulazine is an orally active antihypertensive agent. Losulazine modulates acid phosphatase, 3β-hydroxysteroid dehydrogenase, and *17β-hydroxysteroid* dehydrogenase** activity. Losulazine can be used for the research of hypertension .

HY-105286

BI-135585	11β-HSD	Metabolic Disease
BI-135585 is a potent, selective and orally active *11β-hydroxysteroid* dehydrogenase 1 (11β-HSD1) inhibitor with an IC₅₀** of 13 nM. BI-135585 exhibits >1000-fold selectivity over other hydroxysteroid dehydrogenases. BI-135585 can be used for type 2 diabetes research .

HY-177634

Gatuzosiran	17β-HSD	Metabolic Disease
Gatuzosiran, a siRNA,is a 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) synthesis reducer. It is used for the study of fatty liver disease.

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-113263R

17a-Hydroxypregnenolone (Standard) 2 Publications Verification 17-OHP5 (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .

HY-101930A

(Rac)-BMS-816336	11β-HSD	Metabolic Disease
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and *mouse 11β-hydroxysteroid* dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀**s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability .

HY-177634A

Gatuzosiran sodium	17β-HSD	Metabolic Disease
Gatuzosiran sodium, a siRNA,is a 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) synthesis reducer. It is used for the study of fatty liver disease.

HY-W016604

4'-Hydroxyvalerophenone 4-Pentanoylphenol; 4-Valerylphenol	17β-HSD	Cancer
4'-Hydroxyvalerophenone (Compound 4) is an inhibitor of 17β-hydroxysteroid dehydrogenase (17β-HSD) with an IC₅₀ of 60.52 μM .

HY-N3115

Palbinone	Others	Inflammation/Immunology
Palbinone is a terpenoid isolated from the roots of Paeonia albiflora Pallas, potently inhibits *3α-hydroxysteroid* dehydrogenase (3α-HSD), with an IC₅₀** of 46 nM. Anti-inflammatory activity .

HY-101930

BMS-816336	11β-HSD	Metabolic Disease
BMS-816336 is a novel, potent and orally bioavailable inhibitor against *human 11β-hydroxysteroid* dehydrogenase type 1 (11β-HSD1) enzyme with an IC₅₀** of 3.0 nM .

HY-W754031

11-Dehydrodexamethasone	11β-HSD	Others
11-Dehydrodexamethasone, Dexamethasone (HY-14648) derivative, is a substrate for *11β-hydroxysteroid* dehydrogenase (11β-HSD) 1/2**. 11-Dehydrodexamethasone undergoes conversion to Dexamethasone via reductive activity of 11β-HSD .

HY-158104

LPPM-8	ATF6	Others
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .

HY-128145

HSD17B13-IN-41	17β-HSD	Metabolic Disease
HSD17B13-IN-41 (Compound C) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). HSD17B13-IN-41 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH .

HY-122028

HSD-016	11β-HSD	Metabolic Disease
HSD-016 is a potent, selective and orally active *11β-hydroxysteroid* dehydrogenase type 1 (11β-HSD1) inhibitor with IC₅₀** values of 11, 1 and 8 nM against human, mouse and rat 11β-HSD1, respectively. HSD-016 can be used for type 2 diabetes research .

HY-129433

17β-HSD1-IN-2	17β-HSD	Endocrinology
17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (K_i=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders .

HY-17462R

Adrenosterone (Standard) (+)-Adrenosterone (Standard)	Androgen Receptor Endogenous Metabolite Reference Standards	Endocrinology Cancer
Adrenosterone (Standard) is the analytical standard of Adrenosterone. This product is intended for research and analytical applications. Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-120643A

BMS-823778	11β-HSD	Metabolic Disease
BMS-823778 was developed as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 to inhibit type 2 diabetes .

HY-18057

BVT-3498 AMG-311	11β-HSD	Metabolic Disease
BVT-3498 (AMG-311) is an inhibitor for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) .

HY-N2337R

11beta-Hydroxyprogesterone (Standard) 11β-Hydroxyprogesterone (Standard)	Reference Standards 11β-HSD	Cardiovascular Disease
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

HY-164137

17β-HSD5 inhibitor 2	17β-HSD	Cancer
17β-HSD5 inhibitor 2 (Compound 30) is an inhibitor for *17β-hydroxysteroid* dehydrogenases 5 (17β-HSD 5) with IC₅₀** of 40 nM .

HY-162215

HSD17B13-IN-88	17β-HSD	Metabolic Disease
HSD17B13-IN-88 (Compound 200) is a *17β-Hydroxysteroid* dehydrogenases (HSD17B13) inhibitor with an IC₅₀** of ≤0.1 μM for Estradiol .

HY-113850

CPSA	Aldose Reductase	Neurological Disease Cancer
CPSA is a potent and competitive inhibitor against 20α-hydroxysteroid dehydrogenase (AKR1C1) with a K_i value of 0.86 nM. CPSA is promising for research of lung and endometrial cancers, premature birth and neuronal disorders .

HY-117609

UE2343	11β-HSD	Neurological Disease
UE2343 is an orally available, brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. UE2343 is being investigated for the treatment of Alzheimer's disease .

HY-167696

11β-HSD1-IN-16	11β-HSD	Neurological Disease
11β-HSD1-IN-16 is an inhibitor of the 11β-hydroxysteroid dehydrogenase HSD11B1, demonstrating an IC of 0.34 μM, making it a valuable tool for research on neuropathic pain, inflammatory pain, and occipital neuralgia.

HY-W749520

Zymosterone	Dihydrofolate reductase (DHFR)	Metabolic Disease
Zymosterone is converted into zymosterol, an intermediate in cholesterol synthesis, through the action of the enzyme hydroxysteroid (17β) dehydrogenase 7 (HSD17B7), and this transformation, catalyzed by 3-keto sterol reductase (ERG27), plays a crucial role in the biosynthesis of ergosterol in yeast.

HY-163259

HSD17B13-IN-62	17β-HSD	Metabolic Disease
HSD17B13-IN-62 (141) is a *17β-Hydroxysteroid* dehydrogenases (HSD17B13) inhibitor, with an IC₅₀** of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .

HY-163248

HSD17B13-IN-37	17β-HSD	Metabolic Disease
HSD17B13-IN-37 (78) is a *17β-Hydroxysteroid* dehydrogenases (HSD17B13) inhibitor, with an IC₅₀** of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .

HY-163255

HSD17B13-IN-58	17β-HSD	Metabolic Disease
HSD17B13-IN-58 (96) is a *17β-Hydroxysteroid* dehydrogenases (HSD17B13) inhibitor, with an IC₅₀** of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .

HY-163246

HSD17B13-IN-34	17β-HSD	Metabolic Disease
HSD17B13-IN-34 (75) is a *17β-Hydroxysteroid* dehydrogenases (HSD17B13) inhibitor, with an IC₅₀** of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .

Cat. No.	Product Name	Target	Research Area

HY-17365

Octreotide acetate 15+ Cited Publications SMS 201-995 acetate	Somatostatin Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

HY-125586

β-Amanitin	DNA/RNA Synthesis ADC Payload	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-105055

Didemnin B	Peptides	Cancer
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-P4755

*N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide*	Peptides	Others
N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

HY-125357

Ternatin	Peptides	Metabolic Disease
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes .

HY-158104

LPPM-8	ATF6	Others
LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .

HY-P11783

Surfactin C2	Fungal	Infection
Surfactin C2 is a lipopeptide produced by Bacillus subtilis A18 with antifungal activity. Surfactin C2 acts against Heterobasidion annosum and Heterobasidion parviporum. Surfactin C2 exerts its activity mainly through membrane‑active effects to disrupt fungal cell structures and inhibit mycelial growth. Surfactin C2 can be used for the research of butt rot and root rot of conifers .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113263

17a-Hydroxypregnenolone 2 Publications Verification 17-OHP5	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Classification of Application Fields Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
17a-Hydroxypregnenolone (17-OHP5) is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .

HY-114464

11-Beta-hydroxyandrostenedione 4-Androsten-11β-ol-3,17-dione	Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite 11β-HSD
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a *11β-hydroxysteroid* dehydrogenase (11βHSD) isozymes** inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism .

HY-124529

Lunularin	Structural Classification Human Gut Microbiota Metabolites other families Conocephalum conicum (L.) Dumort. Phenols Polyphenols Plants Endogenous metabolite Source Classification	11β-HSD Endogenous Metabolite
Lunularin is an inhibitor of *11β-hydroxysteroid* dehydrogenase 1, with an IC₅₀ of 45.44 μM and a K_i of 35.8 μM against human 11β-HSD1, and an IC₅₀ of 17.39 μM and a K_i of 10.31 μM against rat 11β-HSD1. Lunularin upregulates the transcription levels of Sirt1 and Hmox1 genes in the liver. Lunularin reduces food intake and body weight gain, and decreases blood glucose levels in mice fed a high-fat diet. Lunularin inhibits LPS-induced TLR4-mediated NF-κB** pathway activation and nitric oxide production. Lunularin inhibits the proliferation and colony formation of renal cancer and colon cancer cells, and exhibits cancer cell-specific cytotoxicity. Lunularin binds to the steroid-binding site of human 11β-HSD1 and the steroid/NADPH-binding region of rat 11β-HSD1, but does not inhibit 11β-HSD2 or mouse 11β-HSD1. Lunularin can be used in research related to diet-induced obesity, renal cancer, colorectal cancer, inflammatory diseases and metabolic syndrome .

HY-105055

Didemnin B	Natural Products Animals Classification of Application Fields Marine natural products Other marine organisms Disease Research Fields Source Classification Cancer	Others
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .

HY-N2337

11beta-Hydroxyprogesterone 4 Publications Verification 11β-Hydroxyprogesterone	Cardiovascular Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification	11β-HSD
11beta-Hydroxyprogesterone is a potent inhibitors of *11β-Hydroxysteroid* dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀** of 10 nM.

HY-17462

Adrenosterone (+)-Adrenosterone	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Androgen Receptor Endogenous Metabolite
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-155534

17β-HSD10-IN-1	Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	17β-HSD
17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of *17β-hydroxysteroid* dehydrogenase type 10 (17β-HSD10)** with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects .

HY-N3115

Palbinone	Other Terpenoids Classification of Application Fields Paeonia lactiflora Pall. Terpenoids Plants Paeoniaceae Disease Research Fields Inflammation/Immunology Source Classification	Others
Palbinone is a terpenoid isolated from the roots of Paeonia albiflora Pallas, potently inhibits *3α-hydroxysteroid* dehydrogenase (3α-HSD), with an IC₅₀** of 46 nM. Anti-inflammatory activity .

HY-17462R

Adrenosterone (Standard) (+)-Adrenosterone (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Androgen Receptor Endogenous Metabolite Reference Standards
Adrenosterone (Standard) is the analytical standard of Adrenosterone. This product is intended for research and analytical applications. Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-N2337R

11beta-Hydroxyprogesterone (Standard) 11β-Hydroxyprogesterone (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards 11β-HSD
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

HY-N12161

3-Acetyl-11-keto-ursolic acid	Ketones, Aldehydes, Acids Rosaceae Plants Eriobotrya japonica (Thunb.) Lindl. Source Classification	Others
3-Acetyl-11-keto-ursolic acid (Compound 18) is a triterpenoid compound derived from Eriobotrya japonicaleaves. 3-Acetyl-11-keto-ursolic acid has 11B-hydroxysteroid dehydrogenase 1 (11b-HSD1) inhibitory activity. 3-Acetyl-11-keto-ursolic acid can be used for anti-diabetes research .

HY-155535

17β-HSD10-IN-2	Monophenols Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Source Classification	17β-HSD
17β-HSD10-IN-2 (compound 11) is a benzothiazolylurea-based inhibitor，targeting to 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10)，a multifunctional mitochondrial enzyme. 17β-HSD10-IN-2 don't lead to mitochondrial off-targets and cytotoxic or neurotoxic effects. 17β-HSD10 inhibitors can be used for research in Alzheimer's disease (AD) and hormone-dependent cancer .

HY-131586

3,7-Dihydroxyflavone Resogalangin	Flavonoids Flavones Plants Fabaceae Zuccagnia punctata Cav. Source Classification	17β-HSD Estrogen Receptor/ERR Aldose Reductase
3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal *17β-hydroxysteroid* dehydrogenase and a redox inhibitor (IC₅₀=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA)** with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm .

HY-N8523

Vibralactone D	Natural Products Microorganisms Source Classification	Others
Vibralactone D (Compound 1) is a metabolite isolated and cultured from natural basidiomycetes Boreostereum vibrans. Vibralactone D shows weak inhibitory activity against isoenzymes of 11b-hydroxysteroid dehydrogenase (HSD) (IC₅₀ 85.7 μM).

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Structural Classification Alkaloids Other Alkaloids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Source Classification	Parasite Phosphodiesterase (PDE)
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

Species:	Human (5)
Tag:	SUMO (1) His (5) Tag Free (1) Myc (1) GST (1)
Source:	HEK293 (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702131

	COLAER_02088 Protein, Collinsella aerofaciens (T189V, V207M) 7beta-hydroxysteroid dehydrogenase; 7beta-HSDH; NADP-dependent 7beta-hydroxysteroid dehydrogenase	Others	E. coli
	The COLAER_02088 Protein, acting as a 7beta-hydroxysteroid dehydrogenase, transforms 7-oxo-lithocholate into chemopreventive UDCA in the human colon, showcasing its role in bile acid metabolism. This enzyme also exhibits reversible reactions, oxidizing UDCA and utilizing NADPH as its preferred electron acceptor, influencing bile acid dynamics and potential therapeutic applications. COLAER_02088 Protein, Collinsella aerofaciens (T189V, V207M) is the recombinant COLAER_02088 protein, expressed by E. coli , with tag free.

HY-P702132

	COLAER_02088 Protein, Collinsella aerofaciens (T189V, V207M, GST) 7beta-hydroxysteroid dehydrogenase; 7beta-HSDH; NADP-dependent 7beta-hydroxysteroid dehydrogenase	Others	E. coli
	The COLAER_02088 Protein, acting as a 7beta-hydroxysteroid dehydrogenase, transforms 7-oxo-lithocholate into chemopreventive UDCA in the human colon, showcasing its role in bile acid metabolism. This enzyme also exhibits reversible reactions, oxidizing UDCA and utilizing NADPH as its preferred electron acceptor, influencing bile acid dynamics and potential therapeutic applications. COLAER_02088 Protein, Collinsella aerofaciens (T189V, V207M, GST) is the recombinant COLAER_02088 protein, expressed by E. coli , with N-GST labeled tag.

HY-P76975

	HSD17B14 Protein, Human (HEK293, His) 17-beta-hydroxysteroid dehydrogenase 14; 17-beta-HSD 14; DHRS10; SDR3; SDR47C1	Human	HEK293
	HSD17B14 protein, with NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity, converts oestradiol to oestrone. Its enzymatic activity extends to both oestradiol and 5-androstene-3-beta,17-beta-diol in vitro, although the physiological substrate remains unidentified. HSD17B14 Protein, Human (HEK293, His) is the recombinant human-derived HSD17B14 protein, expressed by HEK293 , with C-His labeled tag.

HY-P71343

	SULT2A1 Protein, Human (His) Bile Salt Sulfotransferase; Dehydroepiandrosterone Sulfotransferase; DHEA-ST; hydroxysteroid Sulfotransferase; HST; ST2; ST2A3; Sulfotransferase 2A1; ST2A1; SULT2A1; HST; STD	Human	E. coli
	The SULT2A1 protein utilizes PAPS for critical sulfonation of steroids and bile acids in the liver and adrenal glands. Its multifunctional activity extends to a variety of compounds, enhancing its water solubility to facilitate renal excretion. SULT2A1 Protein, Human (His) is the recombinant human-derived SULT2A1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72237

	HSD11B1 Protein, Human (His-SUMO) 11 beta HSD 1; 11 beta HSD1 ; 11 beta hydroxysteroid dehydrogenase 1; 11 DH ; 11-beta hydroxysteroid dehydrogenase; type 1; 11-beta-HSD1; 11-DH; 11DH ; Corticosteroid 11 beta dehydrogenase isozyme 1; Corticosteroid 11-beta-dehydrogenase isozyme 1; CORTRD2; DHI1_HUMAN; HDL; HSD 11; HSD11; HSD11B; HSD11B1; HSD11L; member 1	Human	E. coli
	The proteins encoded by ED genes are involved in a variety of physiological processes. HSD11B1 Protein, Human (His-SUMO) is the recombinant human-derived HSD11B1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P702864

	FOS Protein, Human (His, Myc) Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2	Human	E. coli
	FOS Protein, Human (His, Myc) is the recombinant human-derived FOS, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P71011A

	SULT2B1 Protein, Human (311a.a, C-His) Sulfotransferase Family Cytosolic 2B Member 1; ST2B1; Sulfotransferase 2B1; Alcohol Sulfotransferase; hydroxysteroid Sulfotransferase 2; SULT2B1; HSST2	Human	E. coli
	The SULT2B1 protein uses PAPS to catalyze sulfate conjugation, mainly sulfating cholesterol, and shows significant activity on steroids such as pregnenolone and DHEA.It plays a crucial role in epidermal cholesterol metabolism, regulating epidermal proliferation and differentiation.SULT2B1 Protein, Human (C-His) is the recombinant human-derived SULT2B1 protein, expressed by E.coli , with C-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-114464S1

11-Beta-hydroxyandrostenedione-d7
11-Beta-hydroxyandrostenedione-d₇ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor

HY-113263S

17a-Hydroxypregnenolone-d3
17a-Hydroxypregnenolone-d₃ (17-OHP5-d₃) is the deuterium labeled 17a-Hydroxypregnenolone (HY-113263). 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .

HY-W721874

Adrenosterone-d10

Adrenosterone-d₁₀ ((+)-Adrenosterone-d₁₀) is the deuterium labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-114464S

11-Beta-hydroxyandrostenedione-d4
11-Beta-hydroxyandrostenedione-d₄ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor .

HY-B1588S

Carbenoxolone-d4

Carbenoxolone-d₄ is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties . Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease . Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD . Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop .Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself .

HY-163263S

HSD17B13-IN-80-d3
HSD17B13-IN-80-d3 (179) is a *17β-Hydroxysteroid* dehydrogenases (HSD17B13) inhibitor, with an IC₅₀** of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .

HY-163259S

HSD17B13-IN-62-d3
HSD17B13-IN-62-d3 (176) is a *17β-Hydroxysteroid* dehydrogenases (HSD17B13) inhibitor, with an IC₅₀** of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .

HY-113263S1

17α-Hydroxypregnenolone-13C2,d2
17α-Hydroxypregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled 17α-Hydroxypregnenolone . 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .

HY-W759219

Adrenosterone-13C3

Adrenosterone- ¹³C₃ ((+)-Adrenosterone- ¹³C₃) is the ¹³C-labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-163253S

HSD17B13-IN-56-d3
HSD17B13-IN-56-D3 (Compound 169) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC₅₀ value of ≤ 0.1 μM for estradiol. HSD17B13-IN-56-D3 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) .

HY-163263S1

HSD17B13-IN-80-d2

HSD17B13-IN-80-d₂ (Compound 200) is the the deuterium labeled HSD17B13-IN-80 (HY-163263). HSD17B13-IN-80 is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC₅₀ value of ≤ 0.1 μM for estradiol. HSD17B13-IN-80 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) .

HY-W744064

Diethylstilbestrol-d4

Diethylstilbestrol-d₄ is the deuterium labeled Diethylstilbestrol (HY-14598). Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and?Apoptosis?of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte?Autophagy?Diethylstilbestrol is a?11β-hydroxysteroid dehydrogenase 2 (HSD11B2)?inhibitor.

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (1) Mouse (1)
Application:	IHC-P (3) ICC/IF (4) IP (2) IHC-F (2) WB (4) FC (1)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83303

	HSD17B1 Antibody (YA3048) hydroxysteroid (17-beta) dehydrogenase 1; HSD17; EDHB17; EDH17B2; SDR28C1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	HSD17B1 Antibody (YA3048) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HSD17B1.

HY-P83303A

	HSD17B1 Antibody (YA3048)(PBS only) hydroxysteroid (17-beta) dehydrogenase 1; HSD17; EDHB17; EDH17B2; SDR28C1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	HSD17B1 Antibody (YA3048) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HSD17B1.

HY-P81196

	HSD3B1 Antibody (YA3519) 1 Publications Verification 3BHS1_HUMAN; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase 1; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 1; EC:1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase 1; EC:1.1.1.270; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase. EC:1.1.1.210; Steroid Delta-isomerase 1; EC:5.3.3.1; Trophoblast antigen FDO161G; 3BH; HSDB3A;	WB, ICC/IF	Human
	HSD3B1 Antibody (YA3519) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HSD3B1.

HY-P83598

	ERAB Antibody (YA3343) HSD17B10; ERAB; HADH2; MRPP2; SCHAD; XH98G2; 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	ERAB Antibody (YA3343) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERAB.