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Cat. No.: HY-157676

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HSD17B13-IN-47

HSD17B13-IN-47 (Compound 500) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC₅₀ value of < 0.1 μM for estradiol. HSD17B13-IN-47 can be used for research on liver diseases or metabolic disorders.

For research use only. We do not sell to patients.

CAS No.: 2912455-14-0
Formula: C₃₀H₃₃F₂NO₅S
Molecular Weight:557.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

HSD17B13-IN-47 Chemical Structure

CAS No.: 2912455-14-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All 17β-HSD Isoforms :

17β-HSD5/AKR1C3

Chemical Information

CAS No. 2912455-14-0
Molecular Weight 557.65
Formula C₃₀H₃₃F₂NO₅S
SMILES

COC1=C(C=C(C(C(O)=O)=C1)F)NS(=O)(C2=C(C(C3=CC=C(C=C3)[C@H]4CC[C@H](CC4)C(C)(C)C)=CC=C2)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang G, et al. 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof. U.S. , WO2023023310. 2023-5-11.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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