1. Metabolic Enzyme/Protease
  2. 11β-HSD
  3. BMS-770767

BMS-770767 is an 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor in type 2 diabetes. 11β-HSD1 is an important enzyme that is widely expressed in liver, adipose tissue and other tissues and plays an important role in metabolic diseases such as diabetes and obesity.

For research use only. We do not sell to patients.

BMS-770767 Chemical Structure

BMS-770767 Chemical Structure

CAS No. : 1875067-34-7

Size Price Stock Quantity
5 mg USD 530 In-stock
10 mg USD 855 In-stock
25 mg USD 1715 In-stock
50 mg USD 2750 In-stock
100 mg USD 4400 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMS-770767 is an 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor in type 2 diabetes. 11β-HSD1 is an important enzyme that is widely expressed in liver, adipose tissue and other tissues and plays an important role in metabolic diseases such as diabetes and obesity[1].

Molecular Weight

355.82

Formula

C19H18ClN3O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC12CC(CC2)(C3=NN=C4N3C=CC=C4OC5=C(C=CC=C5)Cl)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (281.04 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8104 mL 14.0520 mL 28.1041 mL
5 mM 0.5621 mL 2.8104 mL 5.6208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8104 mL 14.0520 mL 28.1041 mL 70.2602 mL
5 mM 0.5621 mL 2.8104 mL 5.6208 mL 14.0520 mL
10 mM 0.2810 mL 1.4052 mL 2.8104 mL 7.0260 mL
15 mM 0.1874 mL 0.9368 mL 1.8736 mL 4.6840 mL
20 mM 0.1405 mL 0.7026 mL 1.4052 mL 3.5130 mL
25 mM 0.1124 mL 0.5621 mL 1.1242 mL 2.8104 mL
30 mM 0.0937 mL 0.4684 mL 0.9368 mL 2.3420 mL
40 mM 0.0703 mL 0.3513 mL 0.7026 mL 1.7565 mL
50 mM 0.0562 mL 0.2810 mL 0.5621 mL 1.4052 mL
60 mM 0.0468 mL 0.2342 mL 0.4684 mL 1.1710 mL
80 mM 0.0351 mL 0.1757 mL 0.3513 mL 0.8783 mL
100 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7026 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BMS-770767 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BMS-770767
Cat. No.:
HY-107124
Quantity:
MCE Japan Authorized Agent: