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Gatuzosiran sodium

Gatuzosiran sodium, a siRNA,is a 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) synthesis reducer. It is used for the study of fatty liver disease.

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  • 화학식: C493H609F11N163Na44O311P43S7
  • 분자량:16570.80
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Gatuzosiran sodium Chemical Structure
    Gatuzosiran sodium Chemical Structure
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All 17β-HSD Isoforms

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  • Gatuzosiran sodium Chemical Structure
    Gatuzosiran sodium Chemical Structure RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Cm-Gm-Um-Am-Am-Gm-Am-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Am-Um-Am-Gm-Am-Um-Gm-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)C-sp-Am-sp-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Am-Um-Cm-Am-Gm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-sp-Gm) (1:1), sodium salt
    1/16
  • RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Cm-Gm-Um-Am-Am-Gm-Am-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Am-Um-Am-Gm-Am-Um-Gm-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)C-sp-Am-sp-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Am-Um-Cm-Am-Gm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-sp-Gm) (1:1), sodium salt