11β-HSD1-IN-26
11β-HSD1-IN-26 (Compound 9f) is a type 1 11β-hydroxysteroid dehydrogenase (11β-HSD-1) inhibitor, with an IC50 of 1.6 nM against the human form and 241 nM against the murine form. 11β-HSD1-IN-26 exhibits inhibitory activity against CYP1C19, with an IC50 of 2 μM. 11β-HSD1-IN-26 can be used for research on metabolic syndrome.
For research use only. We do not sell to patients.
- CAS No.: 1610952-07-2
- Formula: C18H16ClN3
- Molecular Weight:309.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 3T3-L1 | IC50 |
293 nM
Compound: 9f
|
Inhibition of 11beta-HSD-1 in mouse 3T3L1 cells
Inhibition of 11beta-HSD-1 in mouse 3T3L1 cells
|
[PMID: 25050169] |
| HEK293 | IC50 |
13 nM
Compound: 9f
|
Inhibition of human recombinant 11beta-HSD-1 expressed in HEK293 cells
Inhibition of human recombinant 11beta-HSD-1 expressed in HEK293 cells
|
[PMID: 25050169] |
| HEK293-EBNA | IC50 |
>10 μM
Compound: 9f
|
Inhibition of human recombinant 11beta-HSD-2 expressed in HEK293 EBNA cells assessed as reduction in cortisone formation ESI mass spectroscopy
Inhibition of human recombinant 11beta-HSD-2 expressed in HEK293 EBNA cells assessed as reduction in cortisone formation ESI mass spectroscopy
|
[PMID: 25050169] |
| HEK293-EBNA | IC50 |
1.6 nM
Compound: 9f
|
Inhibition of human recombinant 11beta-HSD-1 expressed in HEK293 EBNA cells using [3H]-cortisone and NADPH by scintillation proximity assay
Inhibition of human recombinant 11beta-HSD-1 expressed in HEK293 EBNA cells using [3H]-cortisone and NADPH by scintillation proximity assay
|
[PMID: 25050169] |
| HEK293-EBNA | IC50 |
241 nM
Compound: 9f
|
Inhibition of mouse recombinant 11beta-HSD-1 expressed in HEK293 EBNA cells using [3H]-cortisone and NADPH by scintillation proximity assay
Inhibition of mouse recombinant 11beta-HSD-1 expressed in HEK293 EBNA cells using [3H]-cortisone and NADPH by scintillation proximity assay
|
[PMID: 25050169] |
Chemical Information
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CAS No. 1610952-07-2
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Molecular Weight 309.80
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Formula C18H16ClN3
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SMILES
ClC1=CC=C(C=C1)C2(C3=NN=C4C(=CC=CN43)C5CC5)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)