1610952-07-2
Chemical Structure
11β-HSD1-IN-26
- CAS No.: 1610952-07-2
- Formula:C18H16ClN3
- Molecular Weight:309.80
IUPAC Name: 3-(1-(4-chlorophenyl)cyclopropyl)-8-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridine
InChIKey: DSIKPABWAOKGSR-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C=C1)C2(C3=NN=C4C(=CC=CN43)C5CC5)CC2
Biological Activity: 11β-HSD1-IN-26 (Compound 9f) is a type 1 11β-hydroxysteroid dehydrogenase (11β-HSD-1) inhibitor, with an IC50 of 1.6 nM against the human form and 241 nM against the murine form. 11β-HSD1-IN-26 exhibits inhibitory activity against CYP1C19, with an IC50 of 2 μM. 11β-HSD1-IN-26 can be used for research on metabolic syndrome[1].
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11β-HSD1-IN-26 | 11β-HSD1-IN-26 (Compound 9f) is a type 1 11β-hydroxysteroid dehydrogenase (11β-HSD-1) inhibitor, with an IC50 of 1.6 nM against the human form and 241 nM against the murine form. 11β-HSD1-IN-26 exhibits inhibitory activity against CYP1C19, with an IC50 of 2 μM. 11β-HSD1-IN-26 can be used for research on metabolic syndrome. | |||||||||||||||||||||
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Keywords
