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Cat. No.: HY-N12161

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3-Acetyl-11-keto-ursolic acid

Name: 3-Acetyl-11-keto-ursolic acid
Brand: MedChemExpress
SKU: HY-N12161
Price: 450.00 USD
Availability: InStock
Rating: 5 (1 reviews)

3-Acetyl-11-keto-ursolic acid (Compound 18) is a triterpenoid compound derived from Eriobotrya japonicaleaves. 3-Acetyl-11-keto-ursolic acid has 11B-hydroxysteroid dehydrogenase 1 (11b-HSD1) inhibitory activity. 3-Acetyl-11-keto-ursolic acid can be used for anti-diabetes research.

For research use only. We do not sell to patients.

CAS No.: 35959-01-4
Formula: C₃₂H₄₈O₅
Molecular Weight:512.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

3-Acetyl-11-keto-ursolic acid Chemical Structure

CAS No.: 35959-01-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
ASPC1	IC₅₀	33.5 μM Compound: 3	Cytotoxicity against human AsPC1 cells after 72 hrs by MTT assay Cytotoxicity against human AsPC1 cells after 72 hrs by MTT assay	[PMID: 22959527]
HEK293	IC₅₀	1.35 μM Compound: 18	Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as reduction of cortisone to cortisol conversion by scintillation counting Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as reduction of cortisone to cortisol conversion by scintillation counting	[PMID: 20100662]

Chemical Information

CAS No. 35959-01-4
Molecular Weight 512.72
Formula C₃₂H₄₈O₅
SMILES

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@H]([C@@H]4C)C)C(O)=O)=CC([C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)OC(C)=O)C)([H])CC2)C)=O)C
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rollinger JM, et al. 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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