(Rac)-BMS-816336

Cat. No.: HY-101930A: FAQs
Data Sheet Handling Instructions

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(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability.

For research use only. We do not sell to patients.

(Rac)-BMS-816336 Chemical Structure

CAS No. : 1009365-98-3

Size	Price	Stock
Solution
10 mM * 1 mL in DMSO	USD 265	Ask For Quote & Lead Time
Solid
5 mg	USD 350	Ask For Quote & Lead Time
10 mg	USD 550	Ask For Quote & Lead Time
50 mg	USD 1650	Ask For Quote & Lead Time
100 mg	USD 2650	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of (Rac)-BMS-816336:

BMS-816336 In-stock
(R)-BMS-816336 Get quote

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Description

IC₅₀ & Target

IC50: 10 nM (Human 11β-HSD1) and 68 nM (Mouse 11β-HSD1)^[1]

In Vivo

(Rac)-BMS-816336 (compound 6n) has good metabolic stability, and the remaining rates in human, mouse and rats of 88%,82% and 72%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

341.44

Formula

C₂₁H₂₇NO₃

CAS No.

1009365-98-3

Appearance

Solid

Color

White to off-white

SMILES

OC1[C@H]2C[C@@H]3[C@@](C4=CC=CC=C4)(CC(N5CC(O)C5)=O)[C@@H](CC1C3)C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948. [Content Brief]

(Rac)-BMS-816336 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-BMS-8163361009365-98-311β-HSD11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenase11β-HSD1BMS-816336racematemetabolicstabilityInhibitorinhibitorinhibit

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