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AKR1C1-IN-1 

Cat. No.: HY-114009 Purity: >99.0%
Handling Instructions

AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1.

For research use only. We do not sell to patients.

AKR1C1-IN-1 Chemical Structure

AKR1C1-IN-1 Chemical Structure

CAS No. : 4906-68-7

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Description

AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1[1].

IC50 & Target

Ki: 4 nM (AKR1C1), 87 nM (AKR1C2), 4.2 μM (AKR1C3), 18.2 μM (AKR1C4)[1]

In Vitro

AKR1C1-IN-1 potently inhibits the metabolism of progesterone in AKR1C1-overexpressed BAECs, and with an IC50 of 460 nM[1].

Molecular Weight

293.11

Formula

C₁₃H₉BrO₃

CAS No.

4906-68-7

SMILES

O=C(C1=CC(C2=CC=CC=C2)=CC(Br)=C1O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

AKR1C1-IN-1OthersAKR1C1progesteroneInhibitorinhibitorinhibit

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