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Gatuzosiran

(Synonyms: GSK4532990; ARO-HSD)
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Gatuzosiran (GSK4532990; ARO-HSD) is a GalNAc-conjugated siRNA that inhibits HSD17B13. Gatuzosiran downregulates HSD17B13 mRNA and protein levels. Gatuzosiran improves noninvasive biomarkers of liver function enzymes, liver fibrosis, and steatosis associated with metabolic dysfunction-associated steatohepatitis. Gatuzosiran can be used for research on metabolic dysfunction-associated steatohepatitis.

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  • Pureté : 98.89%
  • CAS No.: 2409783-34-0
  • Formule: C493H653F11N163O311P43S7
  • Masse moléculaire:15603.70
  • Stockage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Gatuzosiran Chemical Structure
    Gatuzosiran Chemical Structure
CAS No.: 2409783-34-0
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  • Gatuzosiran Chemical Structure
    Gatuzosiran Chemical Structure RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Cm-Gm-Um-Am-Am-Gm-Am-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Am-Um-Am-Gm-Am-Um-Gm-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)C-sp-Am-sp-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Am-Um-Cm-Am-Gm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-sp-Gm) (1:1)
    1/16
  • RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Cm-Gm-Um-Am-Am-Gm-Am-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Am-Um-Am-Gm-Am-Um-Gm-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)C-sp-Am-sp-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Am-Um-Cm-Am-Gm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-sp-Gm) (1:1)