Search Result

Results for "

upregulates the expression of caspase 3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (49) 11β-HSD (2) Adenosine Receptor (1) Akt (9) AMPK (3) Apoptosis (43) Autophagy (6) Bacterial (4) Bcl-2 Family (30) Cadherin (1) Calcium Channel (1) CDK (3) Cholinesterase (ChE) (1) COX (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Derivative (2) EGFR (2) Environmental Pollutants (1) ERK (5) FAK (2) Farnesyl Transferase (2) FASTK (1) Ferroptosis (3) FOXO (1) Fungal (3) Glutathione Peroxidase (1) GSK-3 (1) HDAC (3) Histone Acetyltransferase (1) HSP (1) HSV (1) IFNAR (1) Interleukin Related (5) JNK (4) Keap1-Nrf2 (4) Lactate Dehydrogenase (2) MDM-2/p53 (11) MEK (1) Microtubule/Tubulin (3) Mitochondrial Metabolism (2) Mitophagy (1) MMP (3) mTOR (3) MyD88 (1) NF-κB (6) NO Synthase (1) NOD-like Receptor (NLR) (1) p38 MAPK (12) PAK (1) PARP (11) PD-1/PD-L1 (1) PI3K (9) PKC (1) PPAR (2) RAR/RXR (1) Ras (2) Reactive Oxygen Species (ROS) (12) Reference Standards (5) SARS-CoV (1) Smo (1) SOD (2) SRPK (1) STING (2) Survivin (1) Telomerase (1) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (5) Toll-like Receptor (TLR) (3) Topoisomerase (3) VEGFR (8) WDR5 (2) β-catenin (1)
By Research Areas:	Cancer (46) Cardiovascular Disease (5) Endocrinology (1) Infection (6) Inflammation/Immunology (14) Metabolic Disease (7) Neurological Disease (14)

By Targets:

Caspase (49)

11β-HSD (2)

Adenosine Receptor (1)

Akt (9)

AMPK (3)

Apoptosis (43)

Autophagy (6)

Bacterial (4)

Bcl-2 Family (30)

Cadherin (1)

Calcium Channel (1)

CDK (3)

Cholinesterase (ChE) (1)

COX (1)

Cyclin G-associated Kinase (GAK) (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Drug Derivative (2)

EGFR (2)

Environmental Pollutants (1)

ERK (5)

FAK (2)

Farnesyl Transferase (2)

FASTK (1)

Ferroptosis (3)

FOXO (1)

Fungal (3)

Glutathione Peroxidase (1)

GSK-3 (1)

HDAC (3)

Histone Acetyltransferase (1)

HSP (1)

HSV (1)

IFNAR (1)

Interleukin Related (5)

JNK (4)

Keap1-Nrf2 (4)

Lactate Dehydrogenase (2)

MDM-2/p53 (11)

MEK (1)

Microtubule/Tubulin (3)

Mitochondrial Metabolism (2)

Mitophagy (1)

MMP (3)

mTOR (3)

MyD88 (1)

NF-κB (6)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

p38 MAPK (12)

PAK (1)

PARP (11)

PD-1/PD-L1 (1)

PI3K (9)

PKC (1)

PPAR (2)

RAR/RXR (1)

Ras (2)

Reactive Oxygen Species (ROS) (12)

Reference Standards (5)

SARS-CoV (1)

Smo (1)

SOD (2)

SRPK (1)

STING (2)

Survivin (1)

Telomerase (1)

TGF-beta/Smad (1)

TGF-β Receptor (1)

TNF Receptor (5)

Toll-like Receptor (TLR) (3)

Topoisomerase (3)

VEGFR (8)

WDR5 (2)

β-catenin (1)

By Research Areas:

Cancer (46)

Cardiovascular Disease (5)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (14)

Metabolic Disease (7)

Neurological Disease (14)

Inhibitors & Agonists

Natural
Products

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1440

Koumine	Bcl-2 Family	Inflammation/Immunology Cancer
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N3415

Kumatakenin 1 Publications Verification	Apoptosis Autophagy Caspase Ferroptosis SARS-CoV	Neurological Disease Inflammation/Immunology Cancer
Kumatakenin is an orally active apoptosis inducer and autophagy inhibitor, with a K_d value of 2.94 μM for mouse ATG5. Kumatakenin increases the activities of *caspase-3, caspase-8* and *caspase-9, thereby inducing caspase-dependent apoptosis in ovarian cancer cells. Kumatakenin reduces the expression* of chemokines and pro-oncogenic factors in ovarian cancer cells, and inhibits M2 macrophage polarization. Kumatakenin inactivates TRIM65 function, reduces the expression and stability of FASN, and thus inhibits the proliferation, migration, invasion and tumor progression of esophageal cancer cells. Kumatakenin interacts with ATG5 to reduce its protein level, decrease LC3 level, and reduce the number of autophagosomes in the hippocampus. Kumatakenin binds to Eno3 to upregulate its expression, reduce the stability and expression level of IRP1 mRNA, inhibit ferroptosis, alleviate intestinal inflammation, and restore epithelial barrier function. Kumatakenin enhances the efficacy of antibiotics against pathogenic bacteria, inhibits SARS-CoV-2 replication, and reduces cytokine production. Kumatakenin is applicable to research related to ovarian cancer, esophageal cancer, depression and colitis .

HY-N6017

Bakkenolide A	HDAC TNF Receptor Interleukin Related TGF-β Receptor IFNAR PI3K PKC Akt GSK-3 Caspase Apoptosis	Cancer
Bakkenolide A is an anticancer agent. Bakkenolide A reduces the viability of leukemia cells, inhibits cell colony formation and invasion, and downregulates the expression of HDAC3 in cells. Bakkenolide A downregulates the expression of pro-inflammatory cytokines including TNF-α, interleukins such as IL-1β, TGF-β1 and IFN-γ, as well as the expression of PI3K, PDK and PKC in leukemia cells. Bakkenolide A downregulates activated Akt, GSK and Bad, while upregulates Cyto-c, cleaved *Caspase3* and cleaved *Caspase7, induces apoptosis (apoptosis*) in leukemia cells and thereby inhibits inflammatory responses in leukemia cells. Bakkenolide A significantly slows the growth of subcutaneous leukemia tumors in nude mice. Bakkenolide A is applicable to leukemia-related research .

HY-N0660

Jujuboside B	Apoptosis PARP Caspase AMPK Autophagy VEGFR Keap1-Nrf2 STING 11β-HSD Ferroptosis PI3K Akt p38 MAPK ERK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Jujuboside B is a bioactive saponin component isolated from Ziziphi Spinosae Semen (sour jujube seed), with oral efficacy and blood-brain barrier permeability. Jujuboside B induces acute leukemia cell death and drives necroptosis apoptosis by activating the RIPK1/RIPK3/MLKL pathway. Jujuboside B upregulates the expression of NOXA, PARP and *caspase-3, activates AMPK, inhibits the proliferation of breast cancer cells, and induces cell apoptosis and autophagy. Jujuboside B inhibits angiogenesis and tumor growth by blocking the VEGFR-2* signaling pathway. Jujuboside B alleviates liver injury in mice by regulating the Nrf2-STING signaling pathway . Jujuboside B alleviates liver injury by regulating anti-inflammatory responses and downregulating the expression of 11β-HSD2. Jujuboside B induces ferroptosis and overcomes radioresistance in non-small cell lung cancer via the PPARγ-ATF3-Gpx4 signaling pathway. Jujuboside B exerts inhibitory effects on platelet aggregation. Jujuboside B inhibits febrile seizures by suppressing the activity of AMPA receptors. Jujuboside B reverses chronic unpredictable mild stress-promoted tumor progression by blocking the PI3K/Akt and MAPK/ERK pathways and dephosphorylating CREB signaling. Jujuboside B is applicable to related studies on acute leukemia, breast cancer, PM_2.5-induced lung injury, hepatotoxicity, liver injury, colorectal cancer, non-small cell lung cancer, thromboembolic diseases, cardiovascular diseases associated with high platelet aggregation, febrile seizures, and depressive-like phenotypes .

HY-114243

DpC	NF-κB JNK Caspase Apoptosis	Neurological Disease Cancer
DpC is a selective, orally active iron chelator with anticancer activity. DpC acts on signaling pathway-related targets such as JNK, NF-κB, and its activity is competitively inhibited by another iron chelator Dp44mT (HY-18973). By chelating intracellular iron and copper ions in tumor cells to form redox-active complexes, DpC induces oxidative stress, activates the JNK, NF-κB pathways and downregulates IκBα, upregulates the expressions of neuroglobin and cytoglobin, activates *caspase 3/9* to induce tumor cell apoptosis. It also overcomes P-glycoprotein-mediated multidrug resistance through a lysosome-targeting mechanism, and exhibits broad-spectrum synergistic effects when combined with various chemotherapeutic agents. DpC inhibits tumor metastasis and increases TNF-α levels in the tumor microenvironment to enhance endogenous immune responses. DpC is applicable to the research of various malignancies including neuroblastoma, pancreatic cancer, prostate cancer, lung cancer, and breast cancer .

HY-B0877

Halcinonide 1 Publications Verification SQ-18566	Smo Caspase RAR/RXR CDK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of *caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ* to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke .

HY-172209

PPIA-IN-1	p38 MAPK Apoptosis Reactive Oxygen Species (ROS) Caspase Bcl-2 Family	Cancer
PPIA-IN-1 is a PPIA inhibitor with a K_d value of 0.52 μM. PPIA-IN-1 inhibits the PPIA/MAPK signaling pathway to exert antiproliferative activity. PPIA-IN-1 induces G0/G1 cell cycle arrest in cancer cells. PPIA-IN-1 upregulates the expression of Bax and *caspase-3, downregulates Bcl-2* expression, and induces apoptosis in cancer cells. PPIA-IN-1 induces increased ROS levels, DNA damage, endoplasmic reticulum stress, and mitochondrial dysfunction in cancer cells. PPIA-IN-1 exhibits antitumor activity in a mouse colon cancer xenograft model. PPIA-IN-1 can be used for the research of colorectal cancer .

HY-N1983

Caudatin 1 Publications Verification	Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism PARP Caspase Bcl-2 Family VEGFR FAK WDR5 p38 MAPK JNK PPAR	Neurological Disease Inflammation/Immunology Cancer
Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, *caspase-3, -7, -9, upregulates* pro-apoptotic Bad and Bax and downregulates anti-apoptotic Bcl-2 and Bcl-XL. Caudatin suppresses VEGF, FAK phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease .

HY-N1970

5,7-Dihydroxychromone 2 Publications Verification	Keap1-Nrf2 Caspase PARP Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection .

HY-N0392

Polygalasaponin F	Toll-like Receptor (TLR) PI3K Akt NF-κB MDM-2/p53 Caspase MEK Bcl-2 Family p38 MAPK Mitophagy Reactive Oxygen Species (ROS) Apoptosis Calcium Channel	Cardiovascular Disease Infection Neurological Disease
Polygalasaponin F is an orally active triterpenoid saponin monomer. Polygalasaponin F downregulates the expression of Bax, p53, *caspase-3, NF-κB* p65 and MEK1; restores and upregulates the expression of Bcl-2; activates the PI3K/Akt signaling pathway; inhibits the phosphorylation of p38 MAPK, nuclear translocation of NF-κB, TLR4-mediated signaling pathway, mitophagy (Mitophagy) and ROS production; enhances cell viability and suppresses apoptosis (Apoptosis). Polygalasaponin F maintains mitochondrial function, alleviates Ca ²⁺ overload, upregulates pCREB and BDNF, preserves cell viability and inhibits the release of inflammatory cytokines. Polygalasaponin F alleviates lung injury induced by influenza A H1N1 and cerebral ischemia-reperfusion injury. Polygalasaponin F is applicable to researches related to Parkinson's disease, cerebral ischemia, pneumonia induced by influenza A H1N1, stroke and Alzheimer's disease .

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Bcl-2 Family Caspase	Neurological Disease
Thevetiaflavone could upregulate the expression of Bcl-2 and downregulate that of Bax and *caspase-3*.

HY-W075770

Nickel(II) oxide Nickel monoxide	Environmental Pollutants Apoptosis Reactive Oxygen Species (ROS) Caspase TGF-beta/Smad p38 MAPK Akt PI3K	Infection Metabolic Disease Cancer
Nickel(II) oxide (nickel monoxide) is a chemical warfare agent that can enter the body through the respiratory tract and other routes, distributing to organs such as the lungs and testes. The nanoparticle form of nickel(II) oxide (NiO NPs) exhibits antibacterial, anti-leishmanial, anti-diabetic, and anti-cancer activities. NiO NPs can be activated by ultraviolet and visible light, generating reactive oxygen species (ROS). Nickel(II) oxide induces oxidative stress by generating reactive oxygen species, activating the TGF-β1-mediated MAPK and PI3K/AKT pathways, disrupting the MMPs/TIMPs balance, and upregulating the expression of inflammatory factors (IL-1β, IL-6) and apoptosis-related molecules (Bax, *caspase-3, p53), while inhibiting the activity of the anti-apoptotic molecule Bcl-2*. Nickel(II) oxide induces cytotoxicity, promotes fibrosis, triggers inflammatory responses, and causes apoptosis. Nickel(II) oxide can be applied in research on the safety assessment of nanomaterials, such as in the context of pulmonary fibrosis and reproductive system toxicity .

HY-170935

SRSF1-IN-1	SRPK PARP Caspase Apoptosis Autophagy	Cancer
SRSF1-IN-1 is a SRSF1 inhibitor. SRSF1-IN-1 inhibits SRSF1 expression, thereby modulating the splicing of Bcl-x pre-mRNA. SRSF1-IN-1 inhibits the proliferation of various cancer cells. SRSF1-IN-1 induces apoptosis in gastric cancer cells, reduces Bcl-xl expression, and upregulates cleaved PARP and *caspase 3. SRSF1-IN-1 induces autophagy* and promotes cell death. SRSF1-IN-1 exhibits anti-tumor activity in a mouse gastric cancer xenograft model. SRSF1-IN-1 can be used for the research of various cancers including liver cancer, gastric cancer, breast cancer, colon cancer, glioma, and melanoma .

HY-N12717

Casuarinin	PAK FASTK HSP p38 MAPK NF-κB NO Synthase COX HSV Caspase TNF Receptor Fungal Apoptosis	Infection Inflammation/Immunology Cancer
Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of *caspase‑3* and elevation of TNF‑α, inhibits the growth of *Candida albicans, and inhibits HSV‑2*. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections .

HY-N5073

Vitexin-4''-O-glucoside 4''-O-Glucosylvitexin	JNK p38 MAPK Interleukin Related TNF Receptor Caspase Lactate Dehydrogenase Apoptosis	Cardiovascular Disease Metabolic Disease
Vitexin-4''-O-glucoside (4''-O-Glucosylvitexin) is an orally active natural flavonoid component with multiple pharmacological effects including antioxidation, anti-inflammation, cytoprotection and anti-apoptosis. Vitexin-4''-O-glucoside regulates the MAPK signaling pathway by downregulating the phosphorylation levels of JNK and p38, thereby blocking endoplasmic reticulum stress responses. Vitexin-4''-O-glucoside alleviates oxidative stress by reducing MDA content and upregulating the activities of SOD and CAT, attenuates inflammation by downregulating the expressions of inflammatory factors TNF-α, IL-1β and IL-6, and also reduces LDH release and inhibits *caspase-3* activation. Vitexin-4''-O-glucoside effectively improves drug-induced acute liver injury and exerts significant protective effects against myocardial hypoxia/reoxygenation injury. Vitexin-4''-O-glucoside can be used in studies on acute liver injury, cardiovascular diseases and myocardial hypoxia-reoxygenation injury .

HY-15872

FTI-277	Farnesyl Transferase Ras ERK mTOR Caspase Apoptosis Akt PI3K Bacterial	Cardiovascular Disease Neurological Disease Cancer
FTI-277 is a farnesyltransferase (FTase) inhibitor. FTI-277 inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 activates *caspase 3, upregulates* Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification .

HY-110038

FTI-277 TFA	Farnesyl Transferase Ras ERK mTOR Apoptosis Caspase Akt PI3K Bacterial	Cardiovascular Disease Neurological Disease Cancer
FTI-277 TFA is a farnesyltransferase (FTase) inhibitor. FTI-277 TFA inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 TFA activates *caspase 3, upregulates* Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 TFA activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 TFA can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification .

HY-161659

Apoptosis inducer 19	Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)	Cancer
Apoptosis inducer 19 (Compound 7g) is an Apoptosis inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and *caspase-3) and downregulates anti-apoptotic protein (Bcl-2). Apoptosis inducer 19 upregulates* cellular reactive oxygen species (ROS) levels and disrupts mitochondrial membrane potential (MMP). Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research .

HY-N1983R

Caudatin (Standard)	Reference Standards Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism PARP Caspase Bcl-2 Family VEGFR FAK WDR5 p38 MAPK JNK PPAR	Neurological Disease Inflammation/Immunology Cancer
Caudatin (Standard) is the analytical standard of Caudatin (HY-N1983). This product is intended for research and analytical applications. Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, *caspase-3, -7, -9, upregulates* pro-apoptotic Bad and Bax and downregulates anti-apoptotic Bcl-2 and Bcl-XL. Caudatin suppresses VEGF, FAK phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease .

HY-15668

ST09	MMP Bcl-2 Family Caspase Apoptosis Drug Derivative	Cancer
ST09 is an efficient and low toxicity Curcumin (HY-N0005) derivative. ST09 significantly inhibits cell migration and downregulates the expression of MMP1, MMP2, and Vimentin. ST09 has strong cytotoxicity to breast cancer cells, such as MDA-MB-231, MCF7 and T47D cells. ST09 induces cell apoptosis by upregulating Bax and cleaved caspase-3/9. ST09 can be used in the research of cancer such as breast cancer .

HY-175815

Apoptosis inducer 44	Apoptosis Bcl-2 Family Caspase MMP Cadherin	Cancer
Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating *caspase-3* cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer .

HY-178942

EGFR/VEGFR2-IN-9	VEGFR EGFR Apoptosis Bcl-2 Family Caspase MDM-2/p53	Cancer
EGFR/VEGFR2-IN-9 (Compound 9b) is an inhibitor of VEGFR-2 (IC₅₀ = 1.325 μM) and EGFR (IC₅₀ = 1.891 μM). EGFR/VEGFR2-IN-9 significantly inhibits the proliferation of multiple cancer cell lines, particularly leukemia cells. EGFR/VEGFR2-IN-9 upregulates the expression levels of Bax, *caspase-3, and p53, while downregulating the expression* of Bcl-2. EGFR/VEGFR2-IN-9 induces apoptosis and arrests the cell cycle in the G1 phase. EGFR/VEGFR2-IN-9 can be used to investigate anti-tumor angiogenesis and multi-drug resistant cancers .

HY-178036

ZM484	MDM-2/p53 Topoisomerase Bcl-2 Family Caspase Cyclin G-associated Kinase (GAK)	Cancer
ZM484 is a potent dual p53-MDM2/TOP1 inhibitor that exhibits antiproliferative and antitumor activity both in vitro and in vivo. ZM484 effectively upregulates p53 and MDM2 proteins and maintains TOP1 inhibitory activity by the release of camptothecin (CPT) and a potent p53-MDM2 inhibitor. ZM484 induces cell cycle arrest and apoptosis by regulating the expression of key apoptosis- and cycle-related proteins, including *caspase-3, Bcl-2, and Cyclin B1*. ZM484 can be used for colorectal cancer research .

HY-N1970R

5,7-Dihydroxychromone (Standard)	Reference Standards Keap1-Nrf2 Caspase PARP Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone (HY-N1970). This product is intended for research and analytical applications. 5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection .

HY-168877

FMP	MDM-2/p53 Reactive Oxygen Species (ROS) Apoptosis Caspase PARP Bcl-2 Family	Cancer
FMP is a Platinum(IV) complexe. FMP significantly upregulates the expression of γ-H2AX and p53. FMP increases the production of ROS. FMP markedly upregulates the expressions of Apoptosis-related proteins (*DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax*). FMP shows antiproliferative activity against breast cancer .

HY-172393

TCF4/β-catenin-IN-1	β-catenin Apoptosis Caspase MDM-2/p53 Bcl-2 Family Cytochrome P450	Cancer
TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells .

HY-N1440R

Koumine (Standard)	Reference Standards Bcl-2 Family	Inflammation/Immunology Cancer
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-118129

Schisandronic acid Ganwuweizic acid	PARP Apoptosis	Cancer
Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects .

HY-163983

Tubulin polymerization-IN-68	Microtubule/Tubulin Apoptosis PARP Caspase	Cancer
Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and *caspase-3* and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC₅₀=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration .

HY-147504

Anticancer agent 63	Apoptosis Caspase Bcl-2 Family	Cancer
Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC₅₀ values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer agent 63 induce apoptosis in MCF-7 cells via down-regulating the expression of Bcl-2 and up-regulating the expression of IL-2 and Caspase-3. Anticancer agent 63 also shows antioxidant activity .

HY-175332

Apoptosis inducer 43	Apoptosis Bcl-2 Family Caspase MDM-2/p53	Cancer
Apoptosis inducer 43 is an apoptosis inducer. Apoptosis inducer 43 can induce apoptosis, SubG0-G1 cell cycle arrest, secondary necrosis, and upregulate *caspase-3, p53, and Bax/Bcl-2 expression* in HCT116 cells. Apoptosis inducer 43 can inhibit tumor growth in a solid Ehrlich carcinoma (SEC) mouse model. Apoptosis inducer 43 can be used to study cancers such as colon cancer, leukemia, and non-small cell lung cancer .

HY-N0392R

Polygalasaponin F (Standard)	Reference Standards Toll-like Receptor (TLR) PI3K Akt NF-κB	Inflammation/Immunology Cancer
Polygalasaponin F (Standard) is the analytical standard of Polygalasaponin F. This product is intended for research and analytical applications. Polygalasaponin F is an orally active triterpenoid saponin monomer. Polygalasaponin F downregulates the expression of Bax, p53, *caspase-3, NF-κB* p65 and MEK1; restores and upregulates the expression of Bcl-2; activates the PI3K/Akt signaling pathway; inhibits the phosphorylation of p38 MAPK, nuclear translocation of NF-κB, TLR4-mediated signaling pathway, mitophagy (Mitophagy) and ROS production; enhances cell viability and suppresses apoptosis (Apoptosis). Polygalasaponin F maintains mitochondrial function, alleviates Ca ²⁺ overload, upregulates pCREB and BDNF, preserves cell viability and inhibits the release of inflammatory cytokines. Polygalasaponin F alleviates lung injury induced by influenza A H1N1 and cerebral ischemia-reperfusion injury. Polygalasaponin F is applicable to researches related to Parkinson's disease, cerebral ischemia, pneumonia induced by influenza A H1N1, stroke and Alzheimer's disease.

HY-176718

VEGFR-2-IN-69	Caspase CDK Telomerase VEGFR	Cancer
VEGFR-2-IN-69 (Compound 5A) is a dual inhibitor of VEGFR-2 and Telomerase, which upregulates the expression of *caspase 3, caspase* 8 and caspase 9, while downregulating CDK-2, CDK-4 and CDK-6. VEGFR-2-IN-69 exhibits an IC₅₀ of 15.46 µM against HCT116 cells .

HY-175037

DNH28	NF-κB p38 MAPK Bcl-2 Family Caspase Apoptosis	Cancer
DNH28 is a potent NF-κB and MAPK inhibitor with an IC₅₀ of 0.93 μM against HepG2 cells. DNH28 promotes apoptosis by down-regulating the expression of Bcl-2, up-regulating the expression of BAX and Cleaved-caspase-3. DNH28 blocks the cell cycle and inhibits migration. DNH28 can be used for the study of hepatocellular carcinoma (HCC) .

HY-174855

PI3K/mTOR-IN-17	PI3K mTOR Apoptosis Bcl-2 Family MDM-2/p53 Caspase	Cancer
PI3K/mTOR-IN-17 is a dual PI3K and mTOR inhibitor with IC₅₀ values of 1.21 μM (PI3K), and 0.21 μM (mTOR). PI3K/mTOR-IN-17 induces cells caspase-mediated apoptosis by arresting their growth in the G1-phase. PI3K/mTOR-IN-17 upregulates the levels of caspases-3, 7, 8, and 9, p53 expression and Bax/Bcl-2 ratio. PI3K/mTOR-IN-17 suppresses the PI3K/mTOR signaling pathway. PI3K/mTOR-IN-17 can be used for research of cancer, such as non-small cell lung cancer (NSCLC) .

HY-181725

Topoisomerase I-IN-20	Topoisomerase Apoptosis MDM-2/p53 Caspase Bcl-2 Family Reactive Oxygen Species (ROS)	Cancer
Topoisomerase I-IN-20 is a Topoisomerase I inhibitor. Topoisomerase I-IN-20 disrupts DNA synthesis and transcription, thereby inhibiting the proliferation and migration of cancer cells. Topoisomerase I-IN-20 induces S-phase cell cycle arrest and mitochondria-mediated Apoptosis in cancer cells, which is characterized by upregulated expression of p53, Bax, *caspase-3* and *caspase-9, along with downregulated expression* of Bcl-2. Topoisomerase I-IN-20 increases intracellular ROS levels. Topoisomerase I-IN-20 is applicable to lung cancer-related research .

HY-181174

Antioxidant agent-22	SOD Glutathione Peroxidase Caspase Interleukin Related Bcl-2 Family Apoptosis	Cancer
Antioxidant agent-22 is a paraben derivative tetracyclic spermine cyclotriphosphazene compound. Antioxidant agent-22 exhibits antioxidant, anti-Inflammatory, and apoptotic activities. Antioxidant agent-22 significantly upregulates CAT, SOD, *caspase-3* and IL-6 expression, suppresses GSH, IL-1β, and reduces BCL-2 and BAX levels. Antioxidant agent-22 can be used for the research of cancer, such as lung cancer .

HY-180820

Dimethyl bisphenolate	Drug Derivative MDM-2/p53 CDK Reactive Oxygen Species (ROS) Apoptosis Bcl-2 Family Caspase	Cancer
Dimethyl bisphenolate (Compound DMB) is a natural neolignan derivative with orally active anti-tumor activity. Dimethyl bisphenolate can inhibit cancer cells proliferation, invasion and migration. Dimethyl bisphenolate can activate the p53 signaling pathway, upregulate the expression of p21 protein, inhibit the activity of the CDK1-cyclin B1 complex, and cause cells to stall at the G2/M phase. Dimethyl bisphenolate can induce ROS production, upregulate pro-apoptotic proteins Noxa and Bim, downregulate anti-apoptotic protein Bcl-2, activate *caspase-9* and *caspase-3, and ultimately induce cell apoptosis*. Dimethyl bisphenolate can be used for research of glioblastoma .

HY-183330

Topo I/II-IN-3	Topoisomerase Reactive Oxygen Species (ROS) Apoptosis MDM-2/p53 Caspase Bcl-2 Family	Cancer
Topo I/II-IN-3 is a dual inhibitor of topoisomerase I/II (topoisomerase I/II), with an IC₅₀ of 8.99 μM against Topo I and an IC₅₀ of 26.92 μM against Topo II. Topo I/II-IN-3 induces DNA damage, elevates intracellular ROS levels, activates the mitochondrial apoptosis pathway, and exerts cytotoxicity against cancer cells. Topo I/II-IN-3 upregulates the expression of γ-H2AX, p53, activated *caspase-9, Bax* and activated *caspase-3, while downregulating the expression* of Bcl-2. Topo I/II-IN-3 can be used in research related to breast cancer, liver cancer and gastric cancer .

HY-181477

ERK5-IN-7	ERK Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)	Cancer
ERK5-IN-7 is an orally active ERK5 inhibitor with an IC₅₀ of 403.4 nM. ERK5-IN-7 directly inhibits ERK5 kinase activity, and downregulates the phosphorylation level and total protein expression of ERK5. ERK5-IN-7 induces Apoptosis (upregulates Bax, downregulates Bcl-2, and induces *Caspase-3* cleavage). ERK5-IN-7 induces ROS accumulation. ERK5-IN-7 exhibits anticancer effects against Lewis lung cancer .

HY-N16771

Clausenidin	Caspase Apoptosis Bcl-2 Family Bacterial VEGFR	Cancer
Clausenidin is a selective inhibitor targeting apoptosis-related pathways, including the mitochondrial pathway and death receptor pathway, and vascular endothelial growth factor (VEGF). Clausenidin induces mitochondrial membrane depolarization by activating *caspase-3, caspase-8* and *caspase-9, upregulating* the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2. Clausenidin also inhibits VEGF expression and blocks angiogenesis, exerting anti-tumor activity. Clausenidin has inhibitory effects against Mycobacterium tuberculosis (MIC=200 μg/mL). Clausenidin can induce apoptosis in liver cancer cells, arrest the cell cycle in the G2/M phase, and inhibit tumor angiogenesis. Clausenidin can be used in the research of malignant tumors such as liver cancer .

HY-183369

VEGFR/PD-L1-IN-1	VEGFR PD-1/PD-L1 Apoptosis Bcl-2 Family Caspase	Cancer
VEGFR/PD-L1-IN-1 is a VEGFR2 and PD-L1 inhibitor, with IC₅₀ values of 0.383 μM and 134.407 pg/mL against VEGFR2 and PD-L1, respectively. VEGFR/PD-L1-IN-1 enhances the secretion of INF-γ, induces G0/G1 cell cycle arrest in cancer cells, and triggers cancer cell apoptosis. VEGFR/PD-L1-IN-1 upregulates the expression of BAX and *Caspase-3, and downregulates the expression* of Bcl-2. VEGFR/PD-L1-IN-1 can be used in research related to hepatocellular carcinoma, prostate cancer, and colorectal cancer .

HY-183366

HDAC1-IN-14	HDAC Caspase Akt	Inflammation/Immunology Cancer
HDAC1-IN-14 is an indole-based benzamide selective HDAC1 inhibitor with an IC₅₀ of 77 nM. HDAC1-IN-14 acts as an antiproliferative agent, with GI₅₀ values ranging from nanomolar to low micromolar levels in various cancer cells. HDAC1-IN-14 induces G0-G1 cell cycle arrest in colon cancer cells. HDAC1-IN-14 upregulates the expression of *Caspase-3, Cyto-C* and Bax, and downregulates the expression of AKT-1. HDAC1-IN-14 can be used in research related to leukemia, non-small cell lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer .

HY-181843

HDAC-IN-99	HDAC Apoptosis Histone Acetyltransferase Microtubule/Tubulin Caspase	Cancer
HDAC-IN-99 is a histone deacetylase (HDAC) inhibitor with an IC₅₀ of 37.73 nM, and it exhibits potent inhibitory activity against HDAC1 (IC₅₀ = 48.09 nM), HDAC2 (IC₅₀ = 300.28 nM) and HDAC6 (IC₅₀ = 9.16 nM). HDAC-IN-99 exerts broad-spectrum antiproliferative activity in various cancer cell lines. HDAC-IN-99 induces S-phase cell cycle arrest and apoptosis in colon cancer cells, increases the acetylation levels of histone H3, histone H4 and α-tubulin, and upregulates the expression of p21 as well as the cleavage of *caspase-3*. HDAC-IN-99 displays antitumor activity in colon cancer xenograft models. HDAC-IN-99 can be used for the research of colon cancer .

HY-107272

Chuanbeinone 22-Epidelavinone	Cholinesterase (ChE) Apoptosis Bcl-2 Family Caspase Interleukin Related TNF Receptor Toll-like Receptor (TLR) MyD88 NF-κB p38 MAPK	Inflammation/Immunology Cancer
Chuanbeinone (22-Epidelavinone) is an orally active alkaloid found in Fritillaria pallidiflora. Chuanbeinone shows cytotoxicity against mutiple cancer cells and can induces apoptosis and S phase arrest. Chuanbeinone downregulates Bcl-2, upregulates Bax, and activates *caspase-3. Chuanbeinone exerts anti-inflammatory and antitussive effects by reducing pro-inflammatory cytokine (IL-1β, IL-6* and TNF-α) production and mRNA expression, and inhibiting TRIF-, MyD88-, NF-κB-, and MAPK-dependent signaling pathways. Chuanbeinone inhibits AChE and BChE with IC₅₀ values of 7.7 and 0.7 μM. Chuanbeinone can be used for the researches of lung carcinoma, cough, inflammatory diseases .

HY-182469

FuBIG	Lactate Dehydrogenase AMPK FOXO Interleukin Related Reactive Oxygen Species (ROS) TNF Receptor Bcl-2 Family Caspase Apoptosis	Neurological Disease
FuBIG is an iminoguanidine derivative with neuroprotective effects. FuBIGL inhibits L-LDH activation and reduces lactate production. FuBIGL exerts protective effects on inflammatory nerve cells, upregulates the expressions of AMPK, pAMPK and FOXO3, and activates the AMPK pathway in cells. FuBIG exerts anti-inflammatory effects by reducing pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) and increasing the anti-inflammatory cytokine IL-10. FuBIG maintains mitochondrial membrane potential, alleviates mitochondrial dysfunction, reduces ROS production, and relieves oxidative stress. FuBIG upregulates Bcl-2, downregulates Bax and *Caspase-3, and inhibits cell apoptosis (apoptosis). FuBIG improves metabolic disorders in diabetic mice, decreases the levels of LDL-C, ALT* and AST, and increases HDL-C level simultaneously. FuBIG can be used in the research of diabetic neuroinflammation .

HY-178899

C14-Tri-LAN-Gly	NOD-like Receptor (NLR) Caspase Apoptosis	Metabolic Disease
C14-Tri-LAN-Gly is a highly selective and potent NOD1 agonist. C14-Tri-LAN-Gly activates NOD1. C14-Tri-LAN-Gly inhibits the expression of *cleaved-caspase3. C14-Tri-LAN-Gly upregulates* A20 expression. C14-Tri-LAN-Gly protects mice from lethal hepatitis by inhibiting hepatocyte Apoptosis. C14-Tri-LAN-Gly inhibits osteoblastogenesis and promots osteoclastogenesis .

HY-N18905

α-D-Glucosyl hesperidin	Apoptosis Bcl-2 Family Caspase SOD	Endocrinology
α-D-Glucosyl hesperidin is an orally effective structural modification derivative of Hesperidin (HY-15337) with anti-apoptotic (apoptosis) and antioxidant activities. α-D-Glucosyl hesperidin upregulates the expression of the Bcl-2 gene, while downregulating the expressions of the Bax and *caspase-3* genes. α-D-Glucosyl hesperidin increases total antioxidant capacity, SOD and catalase levels, and decreases malondialdehyde and glutathione levels. α-D-Glucosyl hesperidin improves sperm motility, viability and plasma membrane function, while restoring reproductive organ weight and seminiferous tubule structure. α-D-Glucosyl hesperidin increases fertility index and exerts a synergistic protective effect with Proanthocyanidins (HY-N0794) in male rats with testicular ischemia-reperfusion injury. α-D-Glucosyl hesperidin can be used in the research of testicular ischemia-reperfusion injury .

HY-181720

Antitumor agent-214	Caspase PARP Apoptosis	Cancer
Antitumor agent-214 is a chalcone analogue with anti-tumor activity. Antitumor agent-214 induces cell cycle arrest and apoptosis in tumor cells, disrupts mitochondrial metabolism, and upregulates the expression of *caspase 3, caspase* 7 and caspase 9, downregulates PARP1. Antitumor agent-214 can be used for anti-tumor research related to colorectal cancer, breast cancer, lung cancer, and cervical cancer .

HY-184116

A2AR/EGFR-IN-1	Adenosine Receptor EGFR MDM-2/p53 Caspase Bcl-2 Family Apoptosis	Cancer
A2AR/EGFR-IN-1 is a dual A2AR/EGFR inhibitor, with an IC₅₀ of 0.037 μM against A2AR and an IC₅₀ of 8.37 μM against EGFR. A2AR/EGFR-IN-1 induces cell cycle arrest at S and G2/M phases. A2AR/EGFR-IN-1 upregulates the expression of TP53, *Caspase3* and Bax, downregulates the expression of Bcl2, and promotes cell Apoptosis. A2AR/EGFR-IN-1 restores colon crypt structure in an azoxymethane (HY-111375)-induced colorectal cancer model in vivo. A2AR/EGFR-IN-1 can be used for research related to colorectal cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure