EGFR/VEGFR2-IN-9
EGFR/VEGFR2-IN-9 (Compound 9b) is an inhibitor of VEGFR-2 (IC50 = 1.325 μM) and EGFR (IC50 = 1.891 μM). EGFR/VEGFR2-IN-9 significantly inhibits the proliferation of multiple cancer cell lines, particularly leukemia cells. EGFR/VEGFR2-IN-9 upregulates the expression levels of Bax, caspase-3, and p53, while downregulating the expression of Bcl-2. EGFR/VEGFR2-IN-9 induces apoptosis and arrests the cell cycle in the G1 phase. EGFR/VEGFR2-IN-9 can be used to investigate anti-tumor angiogenesis and multi-drug resistant cancers.
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- Fòrmula: C25H23ClN6O3
- Peso molecular:490.94
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas VEGFR
MoreVer todos los productos específicos de isoformas EGFR
MoreVer todos los productos específicos de isoformas Caspase
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Actividad biológica
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EGFR 1.891 μM (IC50) |
Bax |
Caspase 3 |
Bcl-2 |
Chemical Information
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Peso molecular 490.94
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Fòrmula C25H23ClN6O3
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SMILES
COC(C=C12)=C(OC)C=C1N=CN=C2NC(C=C3)=CC=C3/C(C)=N/NC(NC4=CC=C(Cl)C=C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/VEGFR2-IN-9 Related Classifications
HY-178942 Related Classifications
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