country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-175332

Copy Link Print Information

Apoptosis inducer 43

Apoptosis inducer 43 is an apoptosis inducer. Apoptosis inducer 43 can induce apoptosis, SubG0-G1 cell cycle arrest, secondary necrosis, and upregulate caspase-3, p53, and Bax/Bcl-2 expression in HCT116 cells. Apoptosis inducer 43 can inhibit tumor growth in a solid Ehrlich carcinoma (SEC) mouse model. Apoptosis inducer 43 can be used to study cancers such as colon cancer, leukemia, and non-small cell lung cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₂H₂₇F₃N₂O₄
Molecular Weight:560.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Apoptosis inducer 43 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Caspase 3

Bcl-2

Bax

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Alle Caspase Isoform-spezifische Produkte anzeigen :

In Vitro

Apoptosis inducer 43 (Compound 5f) (10 μM) shows anticancer activity and demonstrates an average inhibition percentage exceeding 80% and an average GI₅₀ below 5 μM against NCI 60 cells (leukemia, non-small cell lung, colon, central nervous system, melanoma, ovarian, renal prostate, and breast cancer)^[1].
Apoptosis inducer 43 (1.79-10 μM, 24 h) induces cell cycle arrest, primarily at the SubG0/G1 phase, induces apoptosis in HCT-116 cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

10 μM
Incubation Time:

24 h
Result:

Induced changes in cell cycle distribution, leading to cell cycle arrest in the SubG0-G1 phase, with the percentage of cells in the G0/G1 cycle increasing from 7% (control sample) to 44%.
Resulted in reduction of the percentage of cells in the remaining phases, G0-G1, S and G2/M.

Apoptosis Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

1.79 μM
Incubation Time:

24 h
Result:

Decreased the percentage of live cells and increased the proportion of necrotic cells.
Increased the levels of caspase-3, p53, and Bax proteins, and decreased the level of Bcl-2 protein.

In Vivo

Apoptosis inducer 43 (Compound 5f) (10 mg/kg, i.p., three times weekly, 14 days) demonstrates antitumor effects in solid ehrlich carcinoma (SEC) mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SEC (0.2 mL/mouse) female Swiss albino mice (18-22g) model^[1]
Dosage:

10 mg/kg
Administration:

i.p., three times weekly, 14 days
Result:

Demonstrated antitumor effects, resulting in a 72.5% reduction in tumor volume and a 76% reduction in tumor weight.
Showed small foci of tumor cells with distinct mitotic figures were surrounded by large areas of necrosis.
Reduced mitotic cell counts and VEGF expression.

Chemical Information

Molecular Weight 560.56
Formel C₃₂H₂₇F₃N₂O₄
SMILES

O=C(NC1=CC=CC(C(/C=C/C2=CC=C(C3=CC=CC=C3)C=C2)=O)=C1)C([NH3+])CC4=CC=CC=C4.FC(F)(F)C([O-])=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. El-Haggar R, et al.. Amino acid-modified chalcone derivatives with in vitro and in vivo efficacy against colon cancer. Eur J Med Chem. 2025 Nov 5;297:117963. https://pubmed.ncbi.nlm.nih.gov/40695035/ [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Apoptosis inducer 43

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen