VEGFR/PD-L1-IN-1
VEGFR/PD-L1-IN-1 is a VEGFR2 and PD-L1 inhibitor, with IC50 values of 0.383 μM and 134.407 pg/mL against VEGFR2 and PD-L1, respectively. VEGFR/PD-L1-IN-1 enhances the secretion of INF-γ, induces G0/G1 cell cycle arrest in cancer cells, and triggers cancer cell apoptosis. VEGFR/PD-L1-IN-1 upregulates the expression of BAX and Caspase-3, and downregulates the expression of Bcl-2. VEGFR/PD-L1-IN-1 can be used in research related to hepatocellular carcinoma, prostate cancer, and colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 2675913-94-5
- Formula: C21H18N6O4
- Molecular Weight:418.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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VEGFR2 0.383 μM (IC50) |
Bcl-2 |
Bax |
Caspase 3 |
VEGFR/PD-L1-IN-1 (Compound 8g) potently inhibits the growth of HepG2, PC-3 and HCT-116 cancer cells with IC50 values of 3.93 μM, 9.56 μM and 6.30 μM, respectively, while exhibits low cytotoxicity against normal WI-38 cells[1].
VEGFR/PD-L1-IN-1 induces G0/G1 cell cycle arrest in HepG2 cells, thereby reducing cell progression to the S and G2/M phases[1].
VEGFR/PD-L1-IN-1 induces significant apoptosis and necrosis in HepG2 cells[1].
VEGFR/PD-L1-IN-1 promotes INF-γ secretion and activates the intrinsic apoptotic pathway in HepG2 cells by upregulating the expression of BAX and Caspase-3 and downregulating the expression of Bcl-2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2675913-94-5
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Molecular Weight 418.41
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Formula C21H18N6O4
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SMILES
O=C(N/N=C/C1=CC=C(O)C(OC)=C1)CN(C=NC2=C3C=NN2C4=CC=CC=C4)C3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR/PD-L1-IN-1 Related Classifications
HY-183369 Related Classifications
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