2675913-94-5
Chemical Structure
VEGFR/PD-L1-IN-1
- CAS No.: 2675913-94-5
- Formula:C21H18N6O4
- Molecular Weight:418.41
InChIKey: HBRLYSXGTBYGMG-AUEPDCJTSA-N
SMILES: O=C(N/N=C/C1=CC=C(O)C(OC)=C1)CN(C=NC2=C3C=NN2C4=CC=CC=C4)C3=O
Biological Activity: VEGFR/PD-L1-IN-1 is a VEGFR2 and PD-L1 inhibitor, with IC50 values of 0.383 μM and 134.407 pg/mL against VEGFR2 and PD-L1, respectively. VEGFR/PD-L1-IN-1 enhances the secretion of INF-γ, induces G0/G1 cell cycle arrest in cancer cells, and triggers cancer cell apoptosis. VEGFR/PD-L1-IN-1 upregulates the expression of BAX and Caspase-3, and downregulates the expression of Bcl-2. VEGFR/PD-L1-IN-1 can be used in research related to hepatocellular carcinoma, prostate cancer, and colorectal cancer[1].
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VEGFR/PD-L1-IN-1 | VEGFR/PD-L1-IN-1 is a VEGFR2 and PD-L1 inhibitor, with IC50 values of 0.383 μM and 134.407 pg/mL against VEGFR2 and PD-L1, respectively. VEGFR/PD-L1-IN-1 enhances the secretion of INF-γ, induces G0/G1 cell cycle arrest in cancer cells, and triggers cancer cell apoptosis. VEGFR/PD-L1-IN-1 upregulates the expression of BAX and Caspase-3, and downregulates the expression of Bcl-2. VEGFR/PD-L1-IN-1 can be used in research related to hepatocellular carcinoma, prostate cancer, and colorectal cancer. | |||||||||||||||||||||
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