Tubulin polymerization-IN-68
Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration.
For research use only. We do not sell to patients.
- CAS No.: 2924156-96-5
- Formula: C16H13N3O
- Molecular Weight:263.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PARP-1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
3.568 μM
Compound: 32
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Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 39163776] |
| A549 | IC50 |
1.502 μM
Compound: 32
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 39163776] |
| HepG2 | IC50 |
0.093 μM
Compound: 32
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 39163776] |
| PANC-1 | IC50 |
6.951 μM
Compound: 32
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Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 39163776] |
| U-251 | IC50 |
11.814 μM
Compound: 32
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Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 39163776] |
Chemical Information
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CAS No. 2924156-96-5
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Molecular Weight 263.29
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Formula C16H13N3O
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SMILES
O=C1NC(C2=CC3=C(NC=C3)C=C2)NC4=C1C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-68 Related Classifications
HY-163983 Related Classifications
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