2924156-96-5
Chemical Structure
Tubulin polymerization-IN-68
- CAS No.: 2924156-96-5
- Formula:C16H13N3O
- Molecular Weight:263.29
InChIKey: HCUPKBDQFZGJDF-UHFFFAOYSA-N
SMILES: O=C1NC(C2=CC3=C(NC=C3)C=C2)NC4=C1C=CC=C4
Biological Activity: Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1].
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Tubulin polymerization-IN-68 | Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration. | |||||||||||||||||||||
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Keywords
