Apoptosis inducer 19
Based on 1 Customer Validation
Apoptosis inducer 19 (Compound 7g) is an Apoptosis inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and caspase-3) and downregulates anti-apoptotic protein (Bcl-2). Apoptosis inducer 19 upregulates cellular reactive oxygen species (ROS) levels and disrupts mitochondrial membrane potential (MMP). Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.31%
- No. CAS: 3049296-75-2
- Fòrmula: C22H23NO4
- Peso molecular:365.42
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Bcl-2 |
Bax |
Caspase 3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
17.12 μM
Compound: 7g
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
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[PMID: 38750906] |
| HCT-116 | IC50 |
18.3 μM
Compound: 7g
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
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[PMID: 38750906] |
| HEK293 | IC50 |
39.05 μM
Compound: 7g
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Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
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[PMID: 38750906] |
| MCF7 | IC50 |
16.2 μM
Compound: 7g
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
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[PMID: 38750906] |
| MDA-MB-231 | IC50 |
9.42 μM
Compound: 7g
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
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[PMID: 38750906] |
| MDA-MB-468 | IC50 |
10.13 μM
Compound: 7g
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method
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[PMID: 38750906] |
Chemical Information
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No. CAS 3049296-75-2
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Appearance Solid
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Peso molecular 365.42
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Fòrmula C22H23NO4
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Color Off-white to light yellow
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SMILES
COC1=CC=C(/C=C/C(C2=CC=C(OCC(N3CCCC3)=O)C=C2)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (136.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7366 mL | 13.6829 mL | 27.3658 mL | 68.4144 mL |
| 5 mM | 0.5473 mL | 2.7366 mL | 5.4732 mL | 13.6829 mL | |
| 10 mM | 0.2737 mL | 1.3683 mL | 2.7366 mL | 6.8414 mL | |
| 15 mM | 0.1824 mL | 0.9122 mL | 1.8244 mL | 4.5610 mL | |
| 20 mM | 0.1368 mL | 0.6841 mL | 1.3683 mL | 3.4207 mL | |
| 25 mM | 0.1095 mL | 0.5473 mL | 1.0946 mL | 2.7366 mL | |
| 30 mM | 0.0912 mL | 0.4561 mL | 0.9122 mL | 2.2805 mL | |
| 40 mM | 0.0684 mL | 0.3421 mL | 0.6841 mL | 1.7104 mL | |
| 50 mM | 0.0547 mL | 0.2737 mL | 0.5473 mL | 1.3683 mL | |
| 60 mM | 0.0456 mL | 0.2280 mL | 0.4561 mL | 1.1402 mL | |
| 80 mM | 0.0342 mL | 0.1710 mL | 0.3421 mL | 0.8552 mL | |
| 100 mM | 0.0274 mL | 0.1368 mL | 0.2737 mL | 0.6841 mL |
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