2. Vitamin D Related/Nuclear Receptor Anti-infection Membrane Transporter/Ion Channel PI3K/Akt/mTOR MAPK/ERK Pathway Apoptosis
  3. Bacterial Estrogen Receptor/ERR Sodium Channel PI3K JNK Akt Apoptosis
  4. Propylparaben

Propylparaben  (Synonyms: Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate)

Cat. No.: HY-N2026 Pureté: 99.96%
COA
SDS
Instruction de manipulation Technical Support

Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is an orally active weak estrogen receptor agonist. Propylparaben regulates the PI3K-AKT and JNK signaling pathways, and induces oxidative stress. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods, and can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury.

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Propylparaben

Propylparaben Chemical Structure

CAS No. : 94-13-3

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
1 g En stock
5 g En stock
10 g   Obtenir un devis  
50 g   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

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Based on 1 publication(s) in Google Scholar

Other Forms of Propylparaben:

Propylparaben Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Propylparaben

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  • Activité biologique

  • Pureté et documentation

  • Références

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Description

Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is an orally active weak estrogen receptor agonist. Propylparaben regulates the PI3K-AKT and JNK signaling pathways, and induces oxidative stress. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods, and can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury[1][2][3][4][5].

In Vitro

Propylparaben shows weak estrogenic activity, with a potency approximately 30,000-fold less than 17β-estradiol[1].
Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propylparaben Related Antibodies
In Vivo

Propylparaben (0-1% in diet; dietary; continuous; 28 days) disrupts male reproductive function in immature rats, causing dose-dependent reductions in sperm parameters and serum testosterone[1].
Propylparaben (7.5 mg/kg; p.o.; daily for 8 months) significantly alters the estrous cycle, hormone levels and ovarian reserve, and accelerated ovarian aging in mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Crj:Wistar rats (male, 19-21 days old, 52.5 g) fed with slightly modified AIN93G diet[1]
Dosage: 0; 0.01; 0.1; 1% in diet
Administration: dietary; continuous; 28 days
Result: Reduced final body weight slightly but significantly at 1.00% dietary concentration.
Decreased cauda epididymal sperm reserves and sperm concentrations in a dose-dependent manner.
Decreased daily sperm production (DSP) and sperm production efficiency in the testes in a dose-dependent manner.
Decreased serum testosterone concentration in a dose-dependent manner, with a significant reduction to 64.6% of the control value at the 1.00% dietary concentration.
Animal Model: Cycling wild-type female Swiss mice[5]
Dosage: 7.5 mg/kg
Administration: p.o.; daily for 8 months
Result: Significantly altered the estrous cycle, hormone levels and ovarian reserve.
Accelerated ovarian aging of female mice.
Masse moléculaire

180.20

Formule

C10H12O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCCC)C1=CC=C(O)C=C1
Structure Classification
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (554.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5494 mL 27.7469 mL 55.4939 mL
5 mM 1.1099 mL 5.5494 mL 11.0988 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (11.54 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (11.54 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation

Purity: 99.96%

SDS (396 KB)

COA (244 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.5494 mL 27.7469 mL 55.4939 mL 138.7347 mL
5 mM 1.1099 mL 5.5494 mL 11.0988 mL 27.7469 mL
10 mM 0.5549 mL 2.7747 mL 5.5494 mL 13.8735 mL
15 mM 0.3700 mL 1.8498 mL 3.6996 mL 9.2490 mL
20 mM 0.2775 mL 1.3873 mL 2.7747 mL 6.9367 mL
25 mM 0.2220 mL 1.1099 mL 2.2198 mL 5.5494 mL
30 mM 0.1850 mL 0.9249 mL 1.8498 mL 4.6245 mL
40 mM 0.1387 mL 0.6937 mL 1.3873 mL 3.4684 mL
50 mM 0.1110 mL 0.5549 mL 1.1099 mL 2.7747 mL
60 mM 0.0925 mL 0.4624 mL 0.9249 mL 2.3122 mL
80 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.7342 mL
100 mM 0.0555 mL 0.2775 mL 0.5549 mL 1.3873 mL
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Propylparaben Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propylparaben94-13-3Propyl parahydroxybenzoate Propyl 4-hydroxybenzoateBacterialEstrogen Receptor/ERRSodium ChannelPI3KJNKAktApoptosisNa channelsNa+ channelsPhosphoinositide 3-kinasec-Jun N-terminal kinasePKBProtein kinase Boxidative stressestrus cyclesantral follicleJNK signaling pathwaysPI3K-AKT signaling pathwaysovarian reservespermandrogen receptorsestrogen receptorsInhibitorinhibitorinhibit

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