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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
162 Results for "
hydrolase enzyme
" in MedChemExpress (MCE) Product Catalog:
Products (162)
162 Results for "hydrolase enzyme" in MCE Product Catalog:
3
Target:
3
3 Cited Publications
Research Areas:
LY2183240 is a highly potent blocker of anandamide uptake (IC50= 270 pM; Ki=540 nM). LY2183240 is a potent, covalent inhibitor of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) with an IC50 of 12.4 nM. LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile. LY2183240 also inhibits several other brain serine hydrolases with IC50s of 5.3, 0.09, 8.2 nM for MAG lipase, bh6 and KIAA1363, respectively .
3
Research Areas:
Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets .
1
Target:
Research Areas:
β-Glucosidase, almond is the rate-limiting enzyme in cellulose degradation. β-Glucosidase is a major group among glycoside hydrolases. β-Glucosidase is involved in the degradation of cellulose in soils and has potential for monitoring soil quality .
1
1 Cited Publications
Target:
Research Areas:
DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC50=47 nM.
1
1 Cited Publications
Cat. No.: HY-P701447
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP28; Ubiquitin Specific Peptidase 28; Ubiquitin-Specific-Processing Protease 28; Ubiquitin Carboxyl-Terminal hydrolase 28; Deubiquitinating enzyme 28; Ubiquitin Thioesterase 28; KIAA1515; Ubiquitin Carboxyl-Terminal hydrolase; Ubiquitin Specific Proteas
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P702063
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: USP11; Ubiquitin Specific Peptidase 11; UHX1; Ubiquitin Carboxyl-Terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin Thioesterase 11; Ubiquitin Carboxyl-Terminal hydrolase, X-Linked; Ubiquitin-Specific Processing Protease 11; Ubiquitin-Specific-P
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P71418
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP14; Ubiquitin Specific Peptidase 14; TGT; Ubp6; Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase); Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase); Ubiquitin Carboxyl-Terminal hydrolase 14; Deubiquitinating enzyme 14; Ubiqu
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P702603
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP7; HAUSP; Ubiquitin Specific Peptidase 7; Ubiquitin-Specific-Processing Protease 7; Ubiquitin Carboxyl-Terminal hydrolase 7; Deubiquitinating enzyme 7; Ubiquitin Thioesterase 7; Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated); Herpesvirus-Asso
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P74478
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP7; HAUSP; Ubiquitin Specific Peptidase 7; Ubiquitin-Specific-Processing Protease 7; Ubiquitin Carboxyl-Terminal hydrolase 7; Deubiquitinating enzyme 7; Ubiquitin Thioesterase 7; Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated); Herpesvirus-Asso
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P703232
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP4; Ubiquitin Specific Peptidase 4; UNP; Unph; Ubiquitin Specific Peptidase 4 (Proto-Oncogene); Ubiquitin Carboxyl-Terminal hydrolase 4; Ubiquitous Nuclear Protein Homolog; Deubiquitinating enzyme 4; Ubiquitin Thioesterase 4; Ubiquitin Specific Protease
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P701411
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP15; Ubiquitin Specific Peptidase 15; KIAA0529; UNPH4; Ubiquitin-Specific-Processing Protease 15; Ubiquitin Carboxyl-Terminal hydrolase 15; Deubiquitinating enzyme 15; Ubiquitin Thioesterase 15; Ubiquitin Specific Protease 15; Ubiquitin Thiolesterase 15
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P701450
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP30; Ubiquitin Specific Peptidase 30; Ubiquitin-Specific-Processing Protease 30; Ubiquitin Carboxyl-Terminal hydrolase 30; Deubiquitinating enzyme 30; Ubiquitin Thioesterase 30; Ub-Specific Protease 30; MGC10702; FLJ40511; Ubiquitin Carboxyl-Terminal Hy
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-124700
CAS No.: 1966129-74-7
Research Areas:
LYPLAL1-IN-1 (compound 11) is a selective, covalent, and irreversible inhibitor of the lysophospholipase-like enzyme LYPLAL1 (IC50 = 6 nM). LYPLAL1-IN-1 shows selectivity against other serine hydrolases such as carboxylesterase CES1 (IC50 > 50 μM for CES1). LYPLAL1-IN-1 inhibits the depalmitoylation function of LYPLAL1, blocking its depalmitoylation modification of cyclic GMP-AMP synthase (cGAS), thereby promoting cGAS dimerization and activation, and initiating the cGAS-STING pathway-mediated innate immune response. LYPLAL1-IN-1 can enhance DNA-induced type I interferon production, upregulate PD-L1 expression in tumor cells, and promote the accumulation of tumor-infiltrating CD8 + T cells, with the core function of strengthening the anti-tumor immune response. LYPLAL1-IN-1 is primarily used in tumor immunology research, especially in combination with PD-1/PD-L1 inhibitors .
Cat. No.: HY-W040256
CAS No.: 9001-77-8
Synonyms: ACP
Target:
Cat. No.: HY-18081
CAS No.: 959151-50-9
Target:
Research Areas:
PF 750 is a selective, covalent and brain-penetrant fatty acid amide hydrolase (FAAH) inhibitor. PF 750 covalently carbamylates FAAH's catalytic serine nucleophile to inactivate the enzyme .
Target:
Research Areas:
Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. Enzyme-IN-1 may has potential antiinflammatory properties .
Target:
Research Areas:
mEH-IN-1 (Compound 62) is a potent microsomal epoxide hydrolase (mEH) inhibitor with the IC50 of 2.2 nM. The mEH is a mammalian α/β-fold hydrolase enzyme, expressed in almost all tissues, hydrolyzes a wide range of epoxide containing molecules. The mEH is mainly localized in the endoplasmic reticulum (ER) of eukaryotic cells. mEH-IN-1 can be used for the research of preeclampsia, hypercholanemia and cancer .
Research Areas:
Inulinase is a fructan hydrolase (fructan hydrolase) that catalyzes the hydrolysis of β-(2→1) fructosidic linkages in inulin, producing fructose and oligosaccharides depending on the enzyme's source and type. Inulinase also exhibits hydrolytic activity toward fructose-containing substrates such as sucrose, raffinose and stachyose. Inulinase can be used in studies related to inulin degradation, production of fructose and fructooligosaccharides (FOS), carbohydrate metabolism and food processing .
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Epoxide hydrolase is an enzyme responsible for catalyzing the reaction between epoxides and water, converting epoxide groups into diols. Epoxide hydrolase plays a key role in the metabolism of environmental pollutants and lipids, contributing to detoxification, inflammation responses, and the regulation of cardiovascular system health. Additionally, epoxide hydrolase can be used in asymmetric catalytic reactions, such as the asymmetric ring-opening of epoxides, to produce chiral drug molecules .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
