Octanohydroxamic acid
Based on 1 Customer Validation
Octanohydroxamic acid (N-Hydroxyoctanamide) is a Urease inhibitor. Octanohydroxamic acid acts as a chelating agent that binds to metal cations, thereby assisting in the purification of tin ore. Octanohydroxamic acid is also used as a preservative. Octanohydroxamic acid can be used in research on Escherichia coli infection.
For research use only. We do not sell to patients.
- Purity : 99.86%
- CAS No.: 7377-03-9
- Formula: C8H17NO2
- Molecular Weight:159.23
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Chemical Information
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CAS No. 7377-03-9
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Appearance Solid
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Molecular Weight 159.23
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Formula C8H17NO2
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Color White to off-white
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SMILES
O=C(CCCCCCC)NO
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Synonyms
N-Hydroxyoctanamide; Caprylhydroxamic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (1256.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (31.40 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (31.40 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 6.2802 mL | 31.4011 mL | 62.8022 mL | 157.0056 mL |
| 5 mM | 1.2560 mL | 6.2802 mL | 12.5604 mL | 31.4011 mL | |
| 10 mM | 0.6280 mL | 3.1401 mL | 6.2802 mL | 15.7006 mL | |
| 15 mM | 0.4187 mL | 2.0934 mL | 4.1868 mL | 10.4670 mL | |
| 20 mM | 0.3140 mL | 1.5701 mL | 3.1401 mL | 7.8503 mL | |
| 25 mM | 0.2512 mL | 1.2560 mL | 2.5121 mL | 6.2802 mL | |
| 30 mM | 0.2093 mL | 1.0467 mL | 2.0934 mL | 5.2335 mL | |
| 40 mM | 0.1570 mL | 0.7850 mL | 1.5701 mL | 3.9251 mL | |
| 50 mM | 0.1256 mL | 0.6280 mL | 1.2560 mL | 3.1401 mL | |
| 60 mM | 0.1047 mL | 0.5234 mL | 1.0467 mL | 2.6168 mL | |
| 80 mM | 0.0785 mL | 0.3925 mL | 0.7850 mL | 1.9626 mL | |
| 100 mM | 0.0628 mL | 0.3140 mL | 0.6280 mL | 1.5701 mL |
Octanohydroxamic acid Related Classifications
HY-W001857 Related Classifications
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Keywords
- Octanohydroxamic acid
- 7377-03-9
- N-Hydroxyoctanamide
- Caprylhydroxamic acid
- Biochemical Assay Reagents
- Urease
- Bacterial
- Aspergillus brasiliensis
- Escherichia coli
- Pseudomonas aeruginosa
- ammonia production
- antibacterial
- antimicrobial
- epithelial cells
- hepatic encephalopathy
- urea hydrolysis
- urease
- Inhibitor
- inhibitor
- inhibit