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Cat. No.: HY-175816

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5-HT6R/FAAH modulator 1

5-HT6R/FAAH modulator 1 is a selective serotonin 5-HT6 receptor ligand and the fatty acid amide hydrolase (FAAH) enzyme inhibitor. 5-HT6R/FAAH modulator 1 shows a pK_i of 6.33 (5-HT6) and a pIC₅₀ valuesof 6.29 (FAAH). 5-HT6R/FAAH modulator 1 also slightly inhibits acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) enzymes (pIC₅₀ = 5.12). 5-HT6R/FAAH modulator 1 can inhibit apoptosis and reduce ROS levels. 5-HT6R/FAAH modulator 1 can be used for the research of neurological disease, such as Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

Formula: C₂₆H₃₄N₆O₄
Molecular Weight:494.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

5-HT6R/FAAH modulator 1 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

5-HT₆ Receptor

6.33 (pKi)

All 5-HT Receptor Isoforms :

In Vitro

5-HT6R/FAAH modulator 1 (Compound 23) (0.3-30 μM, 72 h) inhibits HepG2 and SH-SY5Y cells growth^[1].
5-HT6R/FAAH modulator 1 (10 μM, 17 h) increases cell viability and inhibits apoptosis and reduces ROS levels in Aβ1-42-treated HT-22 cells^[1].
5-HT6R/FAAH modulator 1 (0.03-0.15 μM) shows potent antioxidant activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2 and SH-SY5Y cells
Concentration:

0.3, 3 and 30 μM
Incubation Time:

72 h
Result:

Inhibited the growth of HepG2 cells by 30 % at a concentration of 3 μM.
Inhibited cell proliferation by only 44 % at the highest concentration of 30 μM.

In Vivo

5-HT6R/FAAH modulator 1 (Compound 23) (0.3-1 mg/kg, i.p.) reverses memory impairment in MK-801-induced memory impairment rats models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MK-801-induced memory impairment rats models^[1]
Dosage:

0.3 and 1 mg/kg
Administration:

Intraperitoneally injection
Result:

Reversed memory deficits at a dose of 1 mg/kg producing a bell-shape effect.

Chemical Information

Molecular Weight 494.59
Formula C₂₆H₃₄N₆O₄
SMILES

NC1=NC(COC2=CC(C)=CC=C2C)=NC(N3CCN(CC4=CC=C(OC)C(OC)=C4OC)CC3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Czarnota-Łydka K, et al. The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment. Eur J Med Chem. 2025 Nov 15;298:118026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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5-HT6R/FAAH modulator 1

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

5-HT6R/FAAH modulator 1 Related Classifications

HY-175816 Related Classifications